Publication: A new alkaloid and a new benzaldehyde derivative from the twig of Zanthoxylum rhetsa (Roxb.) DC.
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Issued Date
2022
Resource Type
Language
eng
File Type
application/pdf
ISSN
14786419
Rights Holder(s)
Scopus
Bibliographic Citation
Frontiers of Nursing. Vol 9, No.2 (2022), p.215-223
Suggested Citation
Lookpan T., Voravuthikunchai S.P., Sitthisuk P., Poorahong W., Watanapokasin R., Chakthong S. A new alkaloid and a new benzaldehyde derivative from the twig of Zanthoxylum rhetsa (Roxb.) DC.. Frontiers of Nursing. Vol 9, No.2 (2022), p.215-223. doi:10.1080/14786419.2022.2127708 Retrieved from: https://hdl.handle.net/20.500.14740/9101
Abstract
A new alkaloid, 2-acetyl-4-methoxyfuro[2,3-b]quinoline (1), and a new benzaldehyde derivative, (2′S)-4-(2′-hydroxy-3′-methyl-3′-butenoxy)benzaldehyde (2), were isolated from the twig of Zanthoxylum rhetsa (Roxb.) DC. along with twenty-six known compounds (3−28). Their structures were determined by spectroscopic analysis (1D and 2D NMR spectroscopy and HRMS analysis) and comparison with data reported in the literature. Thirteen of the known compounds were evaluated for their cytotoxic activities against human cancer cell lines that included MDA-MB-231, SW1353, A549, and HCT116. (±)-8-Acetonyldihydronitidine (15) showed moderate cytotoxicity toward the SW1353 cancer cell line with an IC50 value of 18.90±0.39 µg/mL, and exhibited weak cytotoxic activity against MDA-MB-231, A549 and HCT116 cell lines with IC50 values of 49.86−71.32 µg/mL. © 2022 Informa UK Limited, trading as Taylor & Francis Group.