Publication:
Pre-procedural Intravenous Lactated Ringer’s Solution Preloading to Prevent Hypotension during Sedation for Elective Colonoscopy

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Issued Date

2017

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-85075030784

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 100, No.10 (2017), p.S107-S112

Suggested Citation

Sriramatr D., Bannakiat P., Kusumaphanyo C. Pre-procedural Intravenous Lactated Ringer’s Solution Preloading to Prevent Hypotension during Sedation for Elective Colonoscopy. Journal of the Medical Association of Thailand. Vol 100, No.10 (2017), p.S107-S112. Retrieved from: https://hdl.handle.net/20.500.14740/4304

Title

Pre-procedural Intravenous Lactated Ringer’s Solution Preloading to Prevent Hypotension during Sedation for Elective Colonoscopy

Author(s)

Sriramatr D.
 Bannakiat P.
 Kusumaphanyo C.

Abstract

Objective: Colonoscopy is a common procedure for diagnostic, therapeutic or surveillance purposes. Pre-procedural fasting and bowel preparation to facilitate the procedure may result in dehydration, which could lead to hypotension during colonoscopy under sedation. The goal of this study is to test the hypothesis that pre-procedural intravenous lactated Ringer’s solution (LRS) preloading decreases the incidence of intra-procedural hypotension during sedation for elective colonoscopy. Material and Method: Sixty ASA 1 to 2 Patients, aged 18 to 60 years presenting for elective colonoscopy were randomized into 2 groups, control (C group) or preloading group (L group). Before procedure, C group received intravenous LRS of 1 hour maintenance while L group received intravenous LRS 200 ml preloading in 15 minutes prior to colonoscopy. Sedation was achieved by intravenous fentanyl 25 mcg and propofol infusion using target-control infusor (TCI) with preset target of propofol blood level 3.5 to 6 mcg/ml. Primary outcome was the incidence of hypotension, defined as >25% decrease in systolic blood pressure from baseline during sedation. Secondary outcome were vasopressor use and post-procedural complications (nausea, vomiting and dizziness). Results: Fifty-three patients, 28 in C group and 25 in L group, completed the study. The incidence of hypotension were 39.3% in C group and 40.0% in L group (p = 0.958). Vasopressor use and post-procedural complications were either not significantly different between groups. Conclusion: Pre-procedural intravenous LRS 200 ml preloading cannot prevent hypotension during sedation for elective colonoscopy in ASA 1 to 2 patients. © 2017 Medical Association of Thailand. All rights reserved.

Subject(s)

Fentanyl
 Hypertensive agent
 Propofol
 Ringer lactate solution
 Adult
 Article
 Blood pressure
 Clinical outcome
 Colonoscopy
 Controlled study
 Decubitus
 Dizziness
 Esophagogastroduodenoscopy
 Heart rate
 Hypotension
 Incidence
 Loading drug dose
 Middle aged
 Nausea
 Oxygen saturation
 Postanesthesia care
 Randomization
 Sedation
 Systolic blood pressure
 Vomiting

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URI

https://hdl.handle.net/20.500.14740/4304

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Scopus: Year 1983-2021

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