Publication:
Oral administration of Kaempferia parviflora did not disturb male reproduction in rats

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Issued Date

2008

Resource Type

Article

File Type

application/pdf

ISSN

9168818

DOI

10.1262/jrd.20028

Other identifier(s)

2-s2.0-55849098119

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Reproduction and Development. Vol 54, No.5 (2008), p.375-380

Suggested Citation

Trisomboon H., Tohei A., Malaivijitnond S., Watanabe G., Taya K. Oral administration of Kaempferia parviflora did not disturb male reproduction in rats. Journal of Reproduction and Development. Vol 54, No.5 (2008), p.375-380. doi:10.1262/jrd.20028 Retrieved from: https://hdl.handle.net/20.500.14740/3891

Title

Oral administration of Kaempferia parviflora did not disturb male reproduction in rats

Author(s)

Trisomboon H.
 Tohei A.
 Malaivijitnond S.
 Watanabe G.
 Taya K.

Abstract

To investigate the androgenic effect of Kaempferia parviflora (KP), a Thai herbal plant, adult male rats were randomized into control and KP-treatment groups. Rats were treated orally with water in the control group and with 1,000 mg/kg/day of KP in the treatment group for 45 days. Blood samples were collected on days 10, 20, 30 and 45 for measurement of the serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone, progesterone and corticosterone levels. The reproductive and non-reproductive organs were dissected on day 45 and weighed. Mating behavior was also observed on days 20 and 30. Body weight was measured throughout the study period. The results showed that KP induced an increase in body weight compared with the controls. There were no significant differences in the weights of either reproductive (testis, seminal vesicle plus coagulating gland, levator ani muscle plus bulbocarvernosus muscle and glans penis, except the prostate gland) or non-reproductive organs (kidney, adrenal gland and gastracnemius muscle). There were no significant differences in serum levels of either FSH or LH between the two groups. The serum testosterone and progesterone levels were insignificantly lower in the KP group during the first 30 days. The serum corticosterone levels in the KP group were lower than those in the controls throughout the study period and were significantly low on days 20 and 30. There were no significant changes in mating behavior in the rats treated with KP. Although KP affected the body weight and serum corticosterone level, it did not affect mating behavior, reproductive and non-reproductive organ weights or hormones related to the reproductive system in the adult male rats. Therefore, we conclude that the testosterone-like effect of KP did not disturb the hypothalamic-pituitary-testicular axis or male reproduction.

Subject(s)

Follitropin
 Luteinizing hormone
 Plant extract
 Animal
 Article
 Blood
 Body weight
 Chemistry
 Comparative study
 Drug effect
 Eating
 Evaluation
 Male
 Oral drug administration
 Organ size
 Plant root
 Randomization
 Rat
 Reproduction
 Sexual behavior
 Wistar rat
 Zingiberaceae
 Administration, Oral
 Animals
 Body Weight
 Eating
 Follicle Stimulating Hormone
 Luteinizing Hormone
 Male
 Organ Size
 Plant Extracts
 Plant Roots
 Random Allocation
 Rats
 Rats, Wistar
 Reproduction
 Sexual Behavior, Animal
 Zingiberaceae
 Glans
 Kaempferia parviflora
 Rattus

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URI

https://hdl.handle.net/20.500.14740/3891

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Scopus: Year 1983-2021

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