Publication:
Lower urinary tract symptoms and its potential relation with late-onset hypogonadism

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Issued Date

2008

Resource Type

Note

File Type

application/pdf

ISSN

13685538

DOI

10.1080/13685530801954026

Other identifier(s)

2-s2.0-45849140201

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Aging Male. Vol 11, No.2 (2008), p.51-55

Suggested Citation

Pradidarcheep W. Lower urinary tract symptoms and its potential relation with late-onset hypogonadism. Aging Male. Vol 11, No.2 (2008), p.51-55. doi:10.1080/13685530801954026 Retrieved from: https://hdl.handle.net/20.500.14740/3999

Title

Lower urinary tract symptoms and its potential relation with late-onset hypogonadism

Author(s)

Pradidarcheep W.

Abstract

The study of the health status of the aging male takes presently a more integrative approach and it appears that ailments typical of male aging, such as lower urinary tract symptoms (LUTS), (visceral) obesity, metabolic syndrome and erectile failure are significantly interrelated. A common denominator of the above ailments is lower-than-normal testosterone levels occurring in a significant proportion of elderly men. This review addresses the potential connections between LUTS and late-onset hypogonadism. In animal studies there appear to be androgen and estrogen receptors in the urothelium and smooth muscle cells of the urethra and bladder of the rat and rabbit, as well as in the neurons in the autonomic ganglia of the prostatic plexus of the male rat. Upon castration electrically evoked relaxations of the smooth muscle of the prostatic urethra were decreased. There is a Rho-kinase activation/endothelin pathway; possibly involved in the increased smooth muscle activity found in both LUTS/benign prostate hyperplasia. Nitric oxide (NO) appears to have a smooth muscle relaxing effect in the urogenital organs. Studies in humans have convincingly shown that phosphodiestererase inhibitors have a beneficial effect on LUTS. More intervention studies should be undertaken to test the clinical validity of the theoretically plausible interrelationship between LUTS and late-onset hypogonadism. © 2008 Informa UK Ltd.

Subject(s)

Androgen receptor
 Angiotensin II
 Endothelin
 Estrogen receptor
 Nitric oxide
 Rho kinase
 Testosterone
 Aging
 Castration
 Disease course
 Enzyme activation
 Enzyme activity
 Human
 Hypogonadism
 Lower urinary tract symptom
 Nonhuman
 Note
 Priority journal
 Prostate hypertrophy
 Age of Onset
 Aging
 Animals
 Humans
 Hypogonadism
 Intra-Abdominal Fat
 Male
 Metabolic Syndrome X
 Nitric Oxide
 Rabbits
 Rats
 Receptors, Androgen
 Testosterone
 Urinary Tract
 Urination Disorders

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URI

https://hdl.handle.net/20.500.14740/3999

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Scopus: Year 1983-2021

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