Publication:
Comparison of the effectiveness of fractional 1550-nm erbium fiber laser and 0.05% tretinoin cream in the treatment of acanthosis nigricans: a prospective, randomized, controlled trial

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Issued Date

2020

Resource Type

Article

File Type

application/pdf

ISSN

2688921

DOI

10.1007/s10103-019-02944-9

Other identifier(s)

2-s2.0-85078302901

Rights Holder(s)

Scopus

Bibliographic Citation

Lasers in Medical Science. Vol 35, No.5 (2020), p.1153-1158

Suggested Citation

Leerapongnan P., Jurairattanaporn N., Kanokrungsee S., Udompataikul M. Comparison of the effectiveness of fractional 1550-nm erbium fiber laser and 0.05% tretinoin cream in the treatment of acanthosis nigricans: a prospective, randomized, controlled trial. Lasers in Medical Science. Vol 35, No.5 (2020), p.1153-1158. doi:10.1007/s10103-019-02944-9 Retrieved from: https://hdl.handle.net/20.500.14740/4484

Title

Comparison of the effectiveness of fractional 1550-nm erbium fiber laser and 0.05% tretinoin cream in the treatment of acanthosis nigricans: a prospective, randomized, controlled trial

Author(s)

Leerapongnan P.
 Jurairattanaporn N.
 Kanokrungsee S.
 Udompataikul M.

Abstract

Acanthosis nigricans is a common dermatological problem. There are currently limited clinical trials to determine the efficacy and safety of laser treatments. To compare the efficacy of fractional 1550-nm erbium fiber laser versus 0.05% tretinoin cream for the treatment of acanthosis nigricans at neck, a randomized, controlled, assessor-blinded study was conducted in 18 subjects with acanthosis nigricans at the neck. All patients were treated with both fractional 1550-nm erbium fiber laser and 0.05% tretinoin cream on each side of the neck. The laser side was treated with three treatment sessions, with a 4-week interval of 1550-nm fractional erbium laser. Another side was treated with 0.05% tretinoin cream daily at bedtime for 12 weeks. We evaluated at baseline, with a 4-week interval until 4 weeks after the last treatment. The efficacy was assessed by skin color ratio, melanin index, average roughness, photographic evaluation, patients’ satisfaction, and the adverse effects. At the study endpoint, week 12, the mean Visiometer-average roughness showed greater reduction in laser-treated side (24.65%) than tretinoin side (22.94%) (p = 0.004). Laser-treated side also showed greater percentage of skin color ratio reduction, melanin index reduction, and better mean of photographic-based evaluation percentage change from the baseline than tretinoin side with no significant different (p = 0.331, p = 0.116, p = 0.327, respectively). The study showed one post-inflammatory hyperpigmentation in tretinoin side. Regarding to the average roughness, fractional 1550-nm erbium fiber laser was superior to 0.05% tretinoin cream for treatment of neck-acanthosis nigricans with less side effect. Fractional 1550-nm erbium fiber laser could be considered as an alternative treatment for acanthosis nigricans. © 2020, Springer-Verlag London Ltd., part of Springer Nature.

Subject(s)

Melanin
 Retinoic acid
 Erbium
 Melanin
 Retinoic acid
 Acanthosis nigricans
 Adult
 Article
 Bedtime dosage
 Clinical article
 Clinical outcome
 Comparative effectiveness
 Controlled study
 Cream
 Erythema
 Female
 Human
 Low level laser therapy
 Male
 Neck
 Patient safety
 Patient satisfaction
 Postinflammatory hyperpigmentation
 Priority journal
 Prospective study
 Randomized controlled trial
 Single blind procedure
 Skin color
 Skin irritation
 Acanthosis nigricans
 Comparative study
 Metabolism
 Middle aged
 Multimodality cancer therapy
 Solid state laser
 Treatment outcome
 Young adult
 Acanthosis Nigricans
 Adult
 Combined Modality Therapy
 Erbium
 Female
 Humans
 Lasers, Solid-State
 Male
 Melanins
 Middle Aged
 Patient Satisfaction
 Prospective Studies
 Treatment Outcome
 Tretinoin
 Young Adult

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URI

https://hdl.handle.net/20.500.14740/4484

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Scopus: Year 1983-2021

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