Publication:
Prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status

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Issued Date

2018

Resource Type

Article

File Type

application/pdf

ISSN

3406199

DOI

10.1007/s00431-018-3210-2

Other identifier(s)

2-s2.0-85050270740

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

European Journal of Pediatrics. Vol 177, No.10 (2018), p.1541-1545

Suggested Citation

Ariyawatkul K., Lersbuasin P. Prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status. European Journal of Pediatrics. Vol 177, No.10 (2018), p.1541-1545. doi:10.1007/s00431-018-3210-2 Retrieved from: https://hdl.handle.net/20.500.14740/5827

Title

Prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status

Author(s)

Ariyawatkul K.
 Lersbuasin P.

Abstract

Vitamin D deficiency is common in Southeast Asia but there are limited data in pregnant women and neonates. This study aimed to determine the prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status. A total of 94 pregnant women and their neonates were included. Clinical data and venous maternal blood for calcium, phosphate, albumin, alkaline phosphatase, magnesium, intact parathyroid hormone (iPTH), and vitamin D (25OHD) were obtained on the day of labor. Cord blood was collected following delivery to evaluate vitamin D status of newborns. Mean serum maternal and cord blood 25OHD levels were 25.42 ± 8.07 and 14.85 ± 5.13 ng/mL. The prevalence of vitamin D deficiency (25OHD < 12 ng/mL) and insufficiency (25OHD 12–20 ng/mL) in cord blood of newborns were 20.2 and 69.1%, respectively. There was a significant correlation between maternal and cord blood vitamin D levels (r = 0.86; P < 0.001). The factors associated with cord blood vitamin D deficiency were low maternal 25OHD level and no vitamin D supplement during pregnancy. Conclusion: There is a high prevalence of vitamin D deficiency among Thai neonates. Adequate prenatal vitamin D supplementation should be implemented as routine antenatal care.What is Known:• Vitamin D deficiency is prevalent in Southeast Asia.• There are widespread vitamin D deficiency among Thai populations including pregnant women.What is New:• There is a high prevalence of vitamin D deficiency among Thai neonates.• The factors associated with cord blood vitamin D deficiency are low maternal vitamin D level and no vitamin D supplement during pregnancy. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.

Subject(s)

25 hydroxyvitamin D
 Albumin
 Alkaline phosphatase
 Calcium
 Magnesium
 Parathyroid hormone
 Phosphate
 Alkaline phosphatase
 Calcium
 Magnesium
 Parathyroid hormone
 Phosphate
 Serum albumin
 Vitamin D
 Albumin blood level
 Alkaline phosphatase blood level
 Article
 Calcium blood level
 Controlled study
 Female
 Human
 Magnesium blood level
 Major clinical study
 Maternal blood
 Maternal serum
 Newborn
 Parathyroid hormone blood level
 Phosphate blood level
 Priority journal
 Umbilical cord blood
 Venous blood
 Vitamin blood level
 Vitamin D deficiency
 Adolescent
 Adult
 Blood
 Fetus blood
 Male
 Metabolism
 Middle aged
 Mother
 Pregnancy
 Prevalence
 Thailand
 Vitamin D deficiency
 Young adult
 Adolescent
 Adult
 Alkaline Phosphatase
 Calcium
 Female
 Fetal Blood
 Humans
 Infant, Newborn
 Magnesium
 Male
 Middle Aged
 Mothers
 Parathyroid Hormone
 Phosphates
 Pregnancy
 Prevalence
 Serum Albumin
 Thailand
 Vitamin D
 Vitamin D Deficiency
 Young Adult

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URI

https://hdl.handle.net/20.500.14740/5827

Collections

Scopus: Year 1983-2021

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