Publication: High-performance magnetic solid-phase extraction-SWASV platform based on mercaptosuccinic acid-capped magnetic nanoparticles for simultaneous analysis of heavy metals in honey samples
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Issued Date
2026-01-01
Resource Type
ISSN
0026265X
Scopus ID
2-s2.0-105024885958
Journal Title
Microchemical Journal
Volume
220
Rights Holder(s)
SCOPUS
Bibliographic Citation
Microchemical Journal Vol.220 (2026)
Suggested Citation
Ruenjaiman J., Sroichot D., Kaewjua K., Siangproh W., Songsrirote K. High-performance magnetic solid-phase extraction-SWASV platform based on mercaptosuccinic acid-capped magnetic nanoparticles for simultaneous analysis of heavy metals in honey samples. Microchemical Journal Vol.220 (2026). doi:10.1016/j.microc.2025.116610 Retrieved from: https://hdl.handle.net/20.500.14740/55282
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Abstract
We report the synthesis of novel mercaptosuccinic acid-functionalized magnetic Fe<inf>3</inf>O<inf>4</inf> nanoparticles (MSA@Fe<inf>3</inf>O<inf>4</inf> NPs) and their integration into an efficient magnetic solid-phase extraction (MSPE) system coupled with electrochemical detection for the simultaneous determination of toxic Cd<sup>2+</sup>, Hg<sup>2+</sup>, and Pb<sup>2+</sup> ions in complex food matrices. The simple fabrication method yielded an adsorbent with high affinity, demonstrating maximum adsorption capacities for Cd<sup>2+</sup>, Hg<sup>2+</sup>, and Pb<sup>2+</sup> were 22.99, 43.29, and 53.76 mg/g, respectively, following the Langmuir isotherm model with pseudo-second-order kinetics. Desorption and reusability studies demonstrated that 0.1 M acetic acid effectively regenerated the adsorbent, achieving more than 90 % desorption efficiency while maintaining high removal performance after five adsorption cycles. The MSA@ Fe<inf>3</inf>O<inf>4</inf> NPs were successfully coupled with an unmodified graphene screen-printed electrode using square-wave anodic stripping voltammetry (SWASV), enabling multiplex detection with well-separated stripping potentials. This combined method significantly enhanced signal intensity with enrichment factors of 4.12–6.24 and achieved low limits of detection down to 10.06 μg/L for Cd<sup>2+</sup>, 5.35 μg/L for Hg<sup>2+</sup>, and 6.42 μg/L for Pb<sup>2+</sup>. The developed approach was validated using the standard addition method for trace metal analysis in real honey samples, showing excellent accuracy with no statistically significant difference compared to the reference inductively-coupled plasma optical emission spectroscopic (ICP-OES) method. Structural and surface characterizations by IR and XPS provided critical insights into the binding mechanisms of the metal ions on the magnetic surface. This work presents a reliable, simple, and high-performance analytical tool for decentralized monitoring of heavy metals in food safety applications.