Publication: Twenty-seven base pair deletion in erythrocyte band 3 protein gene responsible for Southeast Asian ovalocytosis is not common among Southeast Asians
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Issued Date
1998
Resource Type
File Type
application/pdf
ISSN
187143
Other identifier(s)
2-s2.0-0032403187
Rights Holder(s)
Scopus
Bibliographic Citation
Human Biology. Vol 70, No.6 (1998), p.993-1000
Suggested Citation
Kimura M., Shimizu Y., Settheetham-Ishida W., Soemantri A., Tiwawech D., Romphruk A., Duangchan P., Ishida T. Twenty-seven base pair deletion in erythrocyte band 3 protein gene responsible for Southeast Asian ovalocytosis is not common among Southeast Asians. Human Biology. Vol 70, No.6 (1998), p.993-1000. Retrieved from: https://hdl.handle.net/20.500.14740/7187
Abstract
Screening for a 27-bp deletion in the band 3 protein gene that causes Southeast Asian/Melanesian ovalocytosis (SAO) was carried out using the PCR method among 15 Southeast Asian populations of Thailand (Akha, Hmong, Isaan, Red Karen, White Karen, Black Lahu, Lisu, Manni, Shan, and central Thais) and Indonesia (Bugis, Dayak, Javanese, Madurian, and Toraja). Individuals with the 27-bp deletion were identified only in the Bugis of southern Sulawesi, the Dayak of southern Borneo, and Javanese of central Java. The gene frequency of the 27-bp deletion in the general population was rather low: 0.012 and 0.013 in the Dayak and the Bugis, respectively. This restricted ethnic and geographic distribution of the 27-bp deletion suggests (1) local differentiation in the prevalence of this deletion in a given ethnic group and (2) the presence of molecular heterogeneity of SAO.
Subject(s)
Base pairing
Disease detection
Disease diagnosis
Erythrocyte
Gene deletion
Gene frequency
Genetic difference
Genetic heterogeneity
Genetic screening
Human genetics
Ovalocytosis
Protein gene
Southeast Asia
Anion Exchange Protein 1, Erythrocyte
Asia, Southeastern
Asian Continental Ancestry Group
Base Sequence
DNA
Elliptocytosis, Hereditary
Female
Gene Frequency
Genetic Screening
Genetics, Population
Humans
Lymphocytes
Male
Pedigree
Polymerase Chain Reaction
Sequence Deletion
Disease detection
Disease diagnosis
Erythrocyte
Gene deletion
Gene frequency
Genetic difference
Genetic heterogeneity
Genetic screening
Human genetics
Ovalocytosis
Protein gene
Southeast Asia
Anion Exchange Protein 1, Erythrocyte
Asia, Southeastern
Asian Continental Ancestry Group
Base Sequence
DNA
Elliptocytosis, Hereditary
Female
Gene Frequency
Genetic Screening
Genetics, Population
Humans
Lymphocytes
Male
Pedigree
Polymerase Chain Reaction
Sequence Deletion