Publication:
The in vitro anthelmintic activity of the ethanol leaf extracts of Terminalia catappa L. On Fasciola gigantica

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Issued Date

2017

Resource Type

Article

File Type

application/pdf

ISSN

311820

DOI

10.1017/S0031182017001445

Other identifier(s)

2-s2.0-85047061516

Rights Holder(s)

Scopus

Bibliographic Citation

Parasitology. Vol 144, No.14 (2017), p.1931-1942

Suggested Citation

Anuracpreeda P., Chawengkirttikul R., Ngamniyom A., Panyarachun B., Puttarak P., Koedrith P., Intaratat N. The in vitro anthelmintic activity of the ethanol leaf extracts of Terminalia catappa L. On Fasciola gigantica. Parasitology. Vol 144, No.14 (2017), p.1931-1942. doi:10.1017/S0031182017001445 Retrieved from: https://hdl.handle.net/20.500.14740/3990

Title

The in vitro anthelmintic activity of the ethanol leaf extracts of Terminalia catappa L. On Fasciola gigantica

Author(s)

Anuracpreeda P.
 Chawengkirttikul R.
 Ngamniyom A.
 Panyarachun B.
 Puttarak P.
 Koedrith P.
 Intaratat N.

Abstract

At present, there are no medicinal plant extracts currently available for treatment and control of fasciolosis. The present work could provide, for the first study, conclusions on the in vitro fasciolicidal properties of the ethanol extract of Terminalia catappa L. (TcCE) leaves against adult Fasciola gigantica after incubation with RPMI-1640 medium containing the TcCE at various concentrations and times when compared with triclabendazole (TCZ). The relative motility and survival index values of the TcCE-treated flukes decreased at a more rapid rate than the TCZ-treated flukes. The death of the parasites was observed after exposed to TcCE at 3 h incubation with 400, 800 and 1000 μg mL-1, and at 6 h incubation in 100 and 200 μg mL-1. Vacuolization, blebbings and partial disruption on the parasites' tegument were observed by light microscopy. When examined by scanning electron microscopy, TcCE caused similar tegumental alterations in the parasites as those observed in TCZ treatment but with larger damage at comparative incubation periods, consisting of swelling, blebbing, disrupted blebs, loss of spines, leading to the erosion, lesion and eventual disruption of the total tegument. Therefore, the TcCE may exert its fasciolicidal effect against F. gigantica by initially causing the tegumental alteration. © Cambridge University Press 2017.

Subject(s)

Alcohol
 Anthelmintic agent
 Plant extract
 Terminalia catappa extract
 Triclabendazole
 Unclassified drug
 Antiplatyhelmintic agent
 Plant extract
 Adult
 Anthelmintic activity
 Article
 Cause of death
 Cell vacuole
 Comparative study
 Concentration process
 Drug exposure
 Erosion
 Fasciola gigantica
 Fascioliasis
 In vitro study
 Incubation time
 Integument
 Microscopy
 Nonhuman
 Organ injury
 Plant leaf
 Priority journal
 Scanning electron microscopy
 Spine
 Survival index
 Survival rate
 Swelling
 Terminalia catappa
 Animal
 Chemistry
 Drug effect
 Fasciola
 Plant leaf
 Terminalia
 Animals
 Antiplatyhelmintic Agents
 Fasciola
 In Vitro Techniques
 Microscopy, Electron, Scanning
 Plant Extracts
 Plant Leaves
 Terminalia

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URI

https://hdl.handle.net/20.500.14740/3990

Collections

Scopus: Year 1983-2021

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