Publication:
Prognostic Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Oncologic Outcomes of Esophageal Cancer: A Systematic Review and Meta-analysis

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Issued Date

2016

Resource Type

Article

File Type

application/pdf

ISSN

10689265

DOI

10.1245/s10434-015-4869-5

Other identifier(s)

2-s2.0-84958177341

Rights Holder(s)

Scopus

Bibliographic Citation

Annals of Surgical Oncology. Vol 23, No.2 (2016), p.646-654

Suggested Citation

Yodying H., Matsuda A., Miyashita M., Matsumoto S., Sakurazawa N., Yamada M., Uchida E. Prognostic Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Oncologic Outcomes of Esophageal Cancer: A Systematic Review and Meta-analysis. Annals of Surgical Oncology. Vol 23, No.2 (2016), p.646-654. doi:10.1245/s10434-015-4869-5 Retrieved from: https://hdl.handle.net/20.500.14740/5728

Title

Prognostic Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Oncologic Outcomes of Esophageal Cancer: A Systematic Review and Meta-analysis

Author(s)

Yodying H.
 Matsuda A.
 Miyashita M.
 Matsumoto S.
 Sakurazawa N.
 Yamada M.
 Uchida E.

Abstract

Background: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been reported to predict oncologic outcomes in patients with various types of cancer. However, their prognostic value in patients with esophageal cancer is unclear. In this meta-analysis, we evaluated the prognostic significance of NLR and PLR in esophageal cancer patients. Methods: We performed comprehensive searches of electronic databases to identify studies that evaluated the prognostic impact of pretreatment NLR and PLR in esophageal cancer patients. The end points were overall survival (OS), disease-free survival, and clinicopathologic parameters. A meta-analysis using random-effects models was performed to calculate hazard ratios (HRs) or odds ratios with 95 % confidence intervals (CIs). Results: Seven retrospective, observational, cohort studies involving 1540 patients were included. All seven studies evaluated NLR, and four evaluated PLR. Both high NLR (HR 1.40, 95 % CI 1.08–1.81, P = 0.01) and high PLR (HR 1.59, 95 % CI 1.14–2.21, P = 0.006) were significantly predictive of poorer OS. NLR was not a significant predictor of disease-free survival. High PLR (HR 1.85, 95 % CI 1.50–2.28, P < 0.00001) but not NLR was significantly predictive of poorer OS in a subgroup of patients who underwent curative surgery without neoadjuvant chemoradiation. Both high NLR and high PLR were significantly associated with deeper tumor invasion and lymph node metastasis. Conclusions: NLR and PLR are associated with tumor progression and are predictive of poorer survival in patients with esophageal cancer. These ratios may thus help to inform treatment decisions and predict treatment outcomes. © 2015, Society of Surgical Oncology.

Subject(s)

Article
 Cancer patient
 Cancer prognosis
 Cancer surgery
 Chemoradiotherapy
 Cohort analysis
 Data base
 Disease free survival
 Esophagus cancer
 Esophagus surgery
 Human
 Lymph node metastasis
 Meta analysis
 Neutrophil lymphocyte ratio
 Observational study
 Outcome assessment
 Overall survival
 Platelet lymphocyte ratio
 Predictive value
 Retrospective study
 Systematic review
 Tumor invasion
 Cancer staging
 Esophageal Neoplasms
 Lymphocyte
 Multimodality cancer therapy
 Neutrophil
 Pathology
 Prognosis
 Survival rate
 Thrombocyte
 Blood Platelets
 Combined Modality Therapy
 Esophageal Neoplasms
 Humans
 Lymphocytes
 Neoplasm Staging
 Neutrophils
 Prognosis
 Survival Rate

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URI

https://hdl.handle.net/20.500.14740/5728

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Scopus: Year 1983-2021

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