Publication: Pre-arterialisation of the arterialised venous flap: An experimental study in the rat
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Issued Date
2001
Resource Type
File Type
application/pdf
ISSN
71226
Other identifier(s)
2-s2.0-0034757271
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
British Journal of Plastic Surgery. Vol 54, No.7 (2001), p.621-630
Suggested Citation
Wungcharoen B., Santidhananon Y., Chongchet V., Pradidarcheep W. Pre-arterialisation of the arterialised venous flap: An experimental study in the rat. British Journal of Plastic Surgery. Vol 54, No.7 (2001), p.621-630. doi:10.1054/bjps.2001.3675 Retrieved from: https://hdl.handle.net/20.500.14740/6938
Abstract
Arteriovenous fistulae cause haemodynamic and morphological changes to the local venous channels. We have used the concept of preformed arteriovenous fistulae to study the viability improvement of arterialised venous flaps. Five groups of flaps were created using the abdominal skin of the Wistar rat (n = 10 in each group) with a silastic sheet implanted underneath. Group 1 (control) contained a flap without a vascular supply, group 2 (venous perfusion flap) contained a single pedicled skeletonised vein and a draining vein, and group 3 (arterialised venous flap) contained an arteriovenous shunt proximal to the single pedicled skeletonised vein and a draining vein; in group 4 (7 day pre-arterialised flap) the arteriovenous shunt was performed 7 days before the flap was raised in the same procedure as group 3, and in group 5 (14 day pre-arterialised flap) the arteriovenous shunt was performed 14 days before the flap was raised. The surviving surface areas of the flaps in each group, assessed 7 days after raising, were 0%, 22.21%, 54.32%, 62.21% and 97.47%, respectively. There was a statistically significant difference in survival between venous perfusion flaps and arterialised venous flaps (P < 0.05). Only the 14 day pre-arterialised flaps had a statistically significantly larger area of survival than arterialised venous flaps (P < 0.05). Microangioarchitecture of the pre-arterialised group, studied by the microvascular corrosion-cast technique combined with scanning electron microscopy and transmission electron microscopy, revealed dilatation of veins, numerous small neo-vessels and a decrease in or total absence of functioning valves. We conclude that 14-day pre-arterialisation in the rat model improved the survival of arterialised venous flaps by increasing collateral pathways for arterialised blood flow through the flap. © 2001 The British Association of Plastic Surgeons.
Subject(s)
Silastic
Abdomen
Animal experiment
Animal model
Animal tissue
Arteriovenous fistula
Arteriovenous shunt
Article
Collateral circulation
Controlled study
Graft survival
Hemodynamics
Male
Morphology
Nonhuman
Perfusion
Priority journal
Rat
Scanning electron microscopy
Silicone prosthesis
Statistical analysis
Surgical technique
Transmission electron microscopy
Vascularization
Vein dilatation
Abdomen
Animal experiment
Animal model
Animal tissue
Arteriovenous fistula
Arteriovenous shunt
Article
Collateral circulation
Controlled study
Graft survival
Hemodynamics
Male
Morphology
Nonhuman
Perfusion
Priority journal
Rat
Scanning electron microscopy
Silicone prosthesis
Statistical analysis
Surgical technique
Transmission electron microscopy
Vascularization
Vein dilatation