Publication:
Effects of curcumin on restoration and improvement of microvasculature characteristic in diabetic rat’s choroid of eye

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Issued Date

2014

Resource Type

Article

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application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-84929614008

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Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 97, No. (2014), p.S39-S46

Suggested Citation

Khimmaktong W., Petpiboolthai H., Sriya P., Anupunpisit V. Effects of curcumin on restoration and improvement of microvasculature characteristic in diabetic rat’s choroid of eye. Journal of the Medical Association of Thailand. Vol 97, No. (2014), p.S39-S46. Retrieved from: https://hdl.handle.net/20.500.14740/6420

Title

Effects of curcumin on restoration and improvement of microvasculature characteristic in diabetic rat’s choroid of eye

Author(s)

Khimmaktong W.
 Petpiboolthai H.
 Sriya P.
 Anupunpisit V.

Abstract

Objective: To investigate the effect of curcumin on microvasculature changes in STZ-induced diabetic rat’s choroid of eye. Material and Method: Male rats were divided into three groups: control (C) Diabetic rats were induced by streptozotocin (STZ) (60 mg/kg BW) (DM) diabetic rats treated with curcumin (DMC) (200 mg/kg BW). After 8 weeks of experiments, microvasculature changes of rat’s choroid were studied under vascular corrosion cast technique with scanning electron microscope (SEM). Results: There were pathology and destruction of choroid microvasculature of DM group that revealed reduced and shrunken sizes of large and small blood vessels, compared with control group; long posterior ciliary arteries (LPCAs) (C = 113.70±1.38, DM = 83.53±2.70, DMC = 109.64±3.41 μm), choroid arteries (C = 94.97±2.79, DM = 59.36±2.61, DMC= 80.31±3.73 μm), vortex veins (C = 74.11±3.24, DM = 46.71±2.56, DMC = 64.66±3.60 μm), and Choriocapillaris (choroidal capillaries) (C = 13.61±0.62, DM = 4.46±0.24, DMC = 9.96±0.70 μm), respectively. In DM group, LPCAs and Choroid arteries were tortuous and showed shrinkage. Vortex veins became narrow. Choriocapillaris showed the pathological characteristics of vascular lesions including of shrinkage, constriction, microaneurysm and blind ending. Fascinatingly, Choroid microvasculature of the eye in curcumin treated group developed into regenerate and repaired conditions with healthy and normal characteristics. Conclusion: Efficiency of curcumin treatment beneficially repaired and regenerated the redevelopment of choroid’s microvascular complications of eye in 8-week experiments. Potential treatment with curcumin in diabetes has demonstrated in a meaningful way the therapeutic consequences in the improvement and recovery of choroidal blood vessels in eye pathology of diabetic rats. © 2014, Medical Association of Thailand. All Rights Reserved.

Subject(s)

Curcumin
 Glucose
 Streptozocin
 Curcumin
 Nonsteroid antiinflammatory agent
 Animal experiment
 Animal model
 Artery constriction
 Artery dilatation
 Article
 Blood vessel diameter
 Blood vessel function
 Choroid vascularization
 Ciliary artery
 Controlled study
 Diabetes mellitus
 Male
 Microaneurysm
 Microvasculature
 Nonhuman
 Pathology
 Rat
 Scanning electron microscopy
 Supplementation
 Animal
 Capillary
 Choroid
 Diabetes Mellitus, Experimental
 Diabetic Neuropathies
 Drug effects
 Vascularization
 Animals
 Anti-Inflammatory Agents, Non-Steroidal
 Capillaries
 Choroid
 Curcumin
 Diabetes Mellitus, Experimental
 Diabetic Neuropathies
 Male
 Microscopy, Electron, Scanning
 Microvessels
 Rats

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https://hdl.handle.net/20.500.14740/6420

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