Publication: Isomeric separation of methamphetamine by HPLC chiral column
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Issued Date
2001
Resource Type
File Type
application/pdf
ISSN
1252208
Other identifier(s)
2-s2.0-0035734272
Rights Holder(s)
Scopus
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol 84, No.11 (2001), p.1604-1613
Suggested Citation
Lekskulchai V. Isomeric separation of methamphetamine by HPLC chiral column. Journal of the Medical Association of Thailand. Vol 84, No.11 (2001), p.1604-1613. Retrieved from: https://hdl.handle.net/20.500.14740/6839
Author(s)
Abstract
Methamphetamine and its active metabolite, amphetamine, are optically active compounds which, based upon synthetic routes, can be found in two forms; pure d-form and racemic mixture. Analysis of their isomers can help to identify which precursor is currently spreading widely in a given region. Since there are many drugs that can be metabolized to amphetamine/methamphetamine, isomeric separation can be a useful tool for evaluation of these drugs, as well. Indirect method by using N-trifluoroacetyl- l -prolyl chloride (l -TPC) was found to have limited accuracy due to the contribution effect. In this presentation a direct method using HPLC Chirex chiral column 3022 was studied. Although the method gave no base-line separation of two different isomer peaks, it gave good sensitivity, reliability, and linearity. No contribution effect was found in the method presented. It also gave excellent correlation with the l-TPC method.
Subject(s)
Acetic acid derivative
Amphetamine
Fluorine derivative
Methamphetamine
Accuracy
Analytic method
Article
Chiral chromatography
Correlation analysis
Gas chromatography
High performance liquid chromatography
Isomerism
Reliability
Chromatography, Gas
Chromatography, High Pressure Liquid
Humans
Isomerism
Methamphetamine
Amphetamine
Fluorine derivative
Methamphetamine
Accuracy
Analytic method
Article
Chiral chromatography
Correlation analysis
Gas chromatography
High performance liquid chromatography
Isomerism
Reliability
Chromatography, Gas
Chromatography, High Pressure Liquid
Humans
Isomerism
Methamphetamine