Publication:
Determination of silver in personal care nanoproducts and effects on dermal exposure

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0

Issued Date

2015

Resource Type

Article

File Type

application/pdf

ISSN

13880764

DOI

10.1007/s11051-015-3220-1

Other identifier(s)

2-s2.0-84946031818

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Nanoparticle Research. Vol 17, No.11 (2015), p.1-11

Suggested Citation

Wasukan N., Srisung S., Kulthong K., Boonrungsiman S., Maniratanachote R. Determination of silver in personal care nanoproducts and effects on dermal exposure. Journal of Nanoparticle Research. Vol 17, No.11 (2015), p.1-11. doi:10.1007/s11051-015-3220-1 Retrieved from: https://hdl.handle.net/20.500.14740/6038

Title

Determination of silver in personal care nanoproducts and effects on dermal exposure

Author(s)

Wasukan N.
 Srisung S.
 Kulthong K.
 Boonrungsiman S.
 Maniratanachote R.

Abstract

Silver (Ag) is one of the widely used nanomaterials in cosmetics, personal care, and household products. This research aimed to investigate the Ag concentration contained in 20 commercial nanoproducts using a simple and reliable procedure. The exposure and adverse effects of a single topical application of Ag on the skin were also evaluated. Herein, we demonstrated that the technique of wet acid digestion, extraction and detection of Ag with graphite furnace absorption spectrometry were effective for any and all nanoproduct matrices. The Ag morphology was characterized by scanning and transmission electron microscopy equipped with energy-dispersive x-ray spectroscopy. Penetration of Ag was evaluated using a polyethersulfone (PES) membrane through a Franz cell and reconstructed human epidermis (RhE) tissue. A skin irritation test was performed on RhE, an acceptable in vitro model which was in compliance with OECD test guideline 439. The results showed that the initial Ag concentration in the tested nanoproducts ranged between 0.0058 and 94 µg/g. However, particulate Ag was only found in two products, both of a liquid formulation. Silver penetration through a PES membrane (0.12–53 % by weight) was weakly correlated with the initial Ag concentration in each sample, but more so to the product formulation. The liquid products demonstrated the highest percent of average Ag penetration, followed by the semi-solid and solid formulations, respectively. In contrast, neither any Ag diffusion from these products into the RhE tissue nor any irritation or toxicity was detected. This study suggests a screening method to evaluate the Ag level in products and their potential adverse effects on the skin that could be incorporated as a part of risk assessment for nanotechnology products. © 2015, Springer Science+Business Media Dordrecht.

Subject(s)

Absorption spectroscopy
 Energy dispersive spectroscopy
 High resolution transmission electron microscopy
 Risk assessment
 Scanning electron microscopy
 Skin
 Tissue
 Transmission electron microscopy
 X ray spectroscopy
 Exposure
 Health effects
 Nanoproducts
 Penetration
 Skin irritation
 Silver
 Cosmetic
 Polyethersulfone
 Silver nanoparticle
 Absorption spectrophotometry
 Article
 Concentration (parameters)
 Controlled study
 Energy dispersive X ray spectroscopy
 Human
 Human tissue
 In vitro study
 Nanoanalysis
 Nanotechnology
 Practice guideline
 Priority journal
 Risk assessment
 Roentgen spectroscopy
 Scanning electron microscopy
 Skin
 Skin irritation
 Skin test
 Structure analysis
 Transmission electron microscopy

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URI

https://hdl.handle.net/20.500.14740/6038

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Scopus: Year 1983-2021

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