Publication:
Identification of ricinoleic acid as an inhibitor of Ca2+ signal-mediated cell-cycle regulation in budding yeast

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Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

15671356

DOI

10.1111/j.1567-1364.2009.00592.x

Other identifier(s)

2-s2.0-74549196285

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

FEMS Yeast Research. Vol 10, No.1 (2010), p.38-43

Suggested Citation

Attrapadung S., Yoshida J., Kimura K.-I., Mizunuma M., Miyakawa T., Thanomsub B.W. Identification of ricinoleic acid as an inhibitor of Ca2+ signal-mediated cell-cycle regulation in budding yeast. FEMS Yeast Research. Vol 10, No.1 (2010), p.38-43. doi:10.1111/j.1567-1364.2009.00592.x Retrieved from: https://hdl.handle.net/20.500.14740/7621

Title

Identification of ricinoleic acid as an inhibitor of Ca2+ signal-mediated cell-cycle regulation in budding yeast

Author(s)

Attrapadung S.
 Yoshida J.
 Kimura K.-I.
 Mizunuma M.
 Miyakawa T.
 Thanomsub B.W.

Abstract

Free fatty acids exhibit diverse biological effects such as the regulation of immune responses in humans and animals. To investigate the biological effect of fatty acids in the model eukaryotic organism yeast, we examined the activity of various fatty acids in a yeast-based drug-screening system designed to detect the small-molecule compounds that inhibit Ca2+-signal-mediated cell-cycle regulation. Among the fatty acids examined, ricinoleic acid markedly alleviated the deleterious physiological effects induced by the compelled activation of Ca2+ signaling by external CaCl2, such as the polarized bud growth and the growth arrest in the G2 phase. In accordance with the physiological consequences induced by ricinoleic acid, it diminished the Ca2+-induced phosphorylation of Cdc28p at Tyr-19, concomitant with the decrease in the Ca2+-stimulated expression levels of Cln2p and Swe1p. © 2009 Federation of European Microbiological Societies.

Subject(s)

Calcium chloride
 Cyclin dependent kinase 1
 Fatty acid
 Fungal protein
 Protein Cln2p
 Protein Swe1p
 Ricinoleic acid
 Tyrosine
 Unclassified drug
 Article
 Calcium signaling
 Cell cycle G2 phase
 Cell cycle regulation
 Controlled study
 Enzyme phosphorylation
 Fungus growth
 Nonhuman
 Protein expression
 Yeast
 Calcium Chloride
 Calcium Signaling
 CDC2-CDC28 Kinases
 Cell Cycle
 Cell Cycle Proteins
 Cyclins
 Growth Inhibitors
 Phosphorylation
 Protein-Tyrosine Kinases
 Ricinoleic Acids
 Saccharomyces cerevisiae
 Saccharomyces cerevisiae Proteins
 Animalia
 Eukaryota
 Saccharomyces cerevisiae
 Saccharomycetales

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URI

https://hdl.handle.net/20.500.14740/7621

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Scopus: Year 1983-2021

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