Publication:
Craniopharyngiomas presenting as incidentalomas: results of KRANIOPHARYNGEOM 2007

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Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

1386341X

DOI

10.1007/s11102-019-00983-7

Other identifier(s)

2-s2.0-85070947975

Rights Holder(s)

Scopus

Bibliographic Citation

Pituitary. Vol 22, No.5 (2019), p.532-541

Suggested Citation

Boekhoff S., Bison B., Eveslage M., Sowithayasakul P., Müller H.L. Craniopharyngiomas presenting as incidentalomas: results of KRANIOPHARYNGEOM 2007. Pituitary. Vol 22, No.5 (2019), p.532-541. doi:10.1007/s11102-019-00983-7 Retrieved from: https://hdl.handle.net/20.500.14740/5142

Title

Craniopharyngiomas presenting as incidentalomas: results of KRANIOPHARYNGEOM 2007

Author(s)

Boekhoff S.
 Bison B.
 Eveslage M.
 Sowithayasakul P.
 Müller H.L.

Abstract

Purpose: Childhood-onset craniopharyngiomas (CP) are diagnosed due to clinical symptoms (symCP) or incidentally (incCP). We investigated clinical manifestations and outcome in incCPs and symCPs. Methods: IncCP were discovered in 4 (3 m/1 f) and symCP in 214 (101 m/113 f) CP recruited 2007–2014 in KRANIOPHARYNGEOM 2007. Age, sex, height, body mass index (BMI), tumor volume, degree of resection, pre- and postsurgical hypothalamic involvement/lesions, pituitary function and outcome were compared between both subgroups. Results: Reasons for imaging in incCP were cerebral palsy, head trauma, nasal obstruction, and tethered-cord syndrome, whereas headache (44%), visual impairment (25%), and growth retardation (17%) lead to imaging in symCP. Tumor volume at diagnosis was smaller in incCP (median 2.39 cm3; range 0.14–4.10 cm3) when compared with symCP (15.86 cm3; 0.002–286.34 cm3). Age, gender, BMI, height, hydrocephalus, tumor location, and hypothalamic involvement at diagnosis of incCP were within the range of these parameters in symCP. Complete resections were achieved more frequently (3/4 patients) in incCP when compared with symCP (20%). Surgical hypothalamic lesions were distributed similar in incCP and symCP. Irradiation was performed only in symCP (33%). No noticeable differences were observed concerning survival rates, endocrine deficiencies, BMI, height, functional capacity and quality of life of the 4 incCP cases when compared with the symCP cohort. Conclusions: IncCP are rare (1.8%) and characterized by lack of endocrine deficiencies, resulting in normal height and BMI, no hydrocephalus, and smaller tumor volume at diagnosis when compared with symCPs. Outcome of the observed incCP is similar with symCP. Clinical trial registration number: NCT01272622. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Subject(s)

Adolescent
 Age
 Article
 Body height
 Body mass
 Body weight gain
 Cancer radiotherapy
 Cancer surgery
 Cerebral palsy
 Child
 Clinical feature
 Clinical outcome
 Controlled study
 Craniopharyngioma
 Female
 Functional status
 Growth hormone deficiency
 Growth retardation
 Head injury
 Headache
 Hormone deficiency
 Human
 Hydrocephalus
 Hypopituitarism
 Hypothalamic obesity
 Hypothalamus disease
 Hypothalamus lesion
 Imaging
 Incidental finding
 Incidentaloma
 Major clinical study
 Male
 Mental deficiency
 Nausea
 Nose obstruction
 Polydipsia
 Polyuria
 Prematurity
 Preschool child
 Priority journal
 Puberty disorders
 Quality of life
 School child
 Sex difference
 Survival rate
 Symptomatology
 Tethered cord syndrome
 Tumor localization
 Tumor volume
 Visual field defect
 Visual impairment
 Vomiting
 Adrenal tumor
 Craniopharyngioma
 Newborn
 Pathology
 Adolescent
 Adrenal Gland Neoplasms
 Child
 Craniopharyngioma
 Female
 Humans
 Infant, Newborn
 Male

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URI

https://hdl.handle.net/20.500.14740/5142

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Scopus: Year 1983-2021

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