Publication:
The Incidence of K-ras Codon 12 Mutations in Cholangiocarcinoma Detected by Polymerase Chain Reaction Technique

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Issued Date

1998

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-0032062789

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 81, No.5 (1998), p.316-322

Suggested Citation

Wattanasirichaigoon S., Tasanakhajorn U., Jesadapatarakul S. The Incidence of K-ras Codon 12 Mutations in Cholangiocarcinoma Detected by Polymerase Chain Reaction Technique. Journal of the Medical Association of Thailand. Vol 81, No.5 (1998), p.316-322. Retrieved from: https://hdl.handle.net/20.500.14740/7242

Title

The Incidence of K-ras Codon 12 Mutations in Cholangiocarcinoma Detected by Polymerase Chain Reaction Technique

Author(s)

Wattanasirichaigoon S.
 Tasanakhajorn U.
 Jesadapatarakul S.

Abstract

In the study, to analyse a K-ras oncogene mutated at codon 12 in 24 patients with choIangiocarcinomas, four (16.67%) of them contained this point mutation. One of 4 was peripheral and the others were hilar tumors. There was no significant relationship between mutation and clinical features in terms of age, sex, endemic area, tumor location, tumor grading and pathological features. In our study, the incidence of K-ras codon 12 mutation in Thai patients with cholangiocarcinoma was lower than that found in British and Japanese patients. The discrepancy of incidence and type of the mutations, in different races and environment probably indicates that there is/are different etiologic mechanism(s) in the pathogenesis of cholangiocarcinoma.

Subject(s)

DNA
 Adult
 Aged
 Article
 Bile duct carcinoma
 Bile duct tumor
 Clinical trial
 Codon
 Comparative study
 Confidence interval
 Female
 Genetics
 Human
 Intrahepatic bile duct
 Male
 Middle aged
 Molecular genetics
 Nucleotide sequence
 Oncogene ras
 Point mutation
 Polymerase chain reaction
 Sensitivity and specificity
 Adult
 Aged
 Aged, 80 and over
 Base Sequence
 Bile Duct Neoplasms
 Bile Ducts, Intrahepatic
 Cholangiocarcinoma
 Codon
 Confidence Intervals
 DNA, Neoplasm
 Female
 Genes, ras
 Humans
 Male
 Middle Aged
 Molecular Sequence Data
 Point Mutation
 Polymerase Chain Reaction
 Sensitivity and Specificity

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URI

https://hdl.handle.net/20.500.14740/7242

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Scopus: Year 1983-2021

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