Publication:
Simultaneously complete but not partial taste and smell losses were associated with SARS-CoV-2 infection

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Issued Date

2021

Resource Type

Article

Language

eng

File Type

application/pdf

ISSN

12019712

DOI

10.1016/j.ijid.2021.03.083

Other identifier(s)

2-s2.0-85107086900

Rights Holder(s)

Scopus

Bibliographic Citation

International Journal of Infectious Diseases. Vol 106, No. (2021), p.329-337

Suggested Citation

Trachootham D., Thongyen S., Lam-Ubol A., Chotechuang N., Pongpirul W., Prasithsirikul W. Simultaneously complete but not partial taste and smell losses were associated with SARS-CoV-2 infection. International Journal of Infectious Diseases. Vol 106, No. (2021), p.329-337. doi:10.1016/j.ijid.2021.03.083 Retrieved from: https://hdl.handle.net/20.500.14740/7812

Title

Simultaneously complete but not partial taste and smell losses were associated with SARS-CoV-2 infection

Author(s)

Trachootham D.
 Thongyen S.
 Lam-Ubol A.
 Chotechuang N.
 Pongpirul W.
 Prasithsirikul W.

Abstract

Objectives: The aim of this study was to investigate the association between taste and smell losses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and to elucidate whether taste preference influences such taste loss. Methods: A matched case–control study was conducted in 366 Thai participants, including 122 who were confirmed SARS-CoV-2-positive by RT-PCR (case group) and 244 who were SARS-CoV-2-negative (control group). Taste, smell, and appetite changes were assessed by self-reported visual analog scale. Preference for sweet, salty, umami, sour, bitter, and spicy were judged using the validated TASTE-26 questionnaire. Results: Partial taste and smell losses were observed in both groups, while complete losses (ageusia and anosmia) were detected only in the case group. Moreover, only ageusia and anosmia were associated with SARS-CoV-2 positivity (P < 0.001, odds ratio of 14.5 and 27.5, respectively). Taste, smell, and appetite scores were more severely reduced in the case group (P < 0.0001). Multivariate analysis showed that anosmia and ageusia were the best predictors of SARS-CoV-2 positivity, followed by appetite loss and fever. Simultaneous losses of taste and smell but not taste preferences were associated with SARS-CoV-2 positivity (P < 0.01, odds ratio 2.28). Conclusions: Complete, but not partial, losses of taste and smell were the best predictors of SARS-CoV-2 infection. During the current COVID-19 pandemic, healthy persons with sudden simultaneous complete loss of taste and smell should be screened for COVID-19. © 2021 The Author(s)

Subject(s)

Adult
 Aged
 Ageusia
 Anosmia
 Appetite
 Article
 Case control study
 Controlled study
 Coronavirus disease 2019
 Disease association
 Female
 Human
 Loss of appetite
 Major clinical study
 Male
 Odor
 Questionnaire
 Real time polymerase chain reaction
 Smelling
 Taste
 Taste 26 questionnaire
 Taste preference
 Visual analog scale
 Ageusia
 Anosmia
 Complication
 Epidemiology
 Middle aged
 Pandemic
 Pathophysiology
 Adult
 Ageusia
 Anosmia
 Case-Control Studies
 COVID-19
 Humans
 Male
 Middle Aged
 Pandemics

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URI

https://hdl.handle.net/20.500.14740/7812

Collections

Scopus: Year 1983-2021

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