Publication: Enhanced Structural Stability and Controlled Drug Release of Hydrophilic Antibiotic-Loaded Alginate/Soy Protein Isolate Core-Sheath Fibers for Tissue Engineering Applications
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Issued Date
2019
Resource Type
File Type
application/pdf
ISSN
12299197
Other identifier(s)
2-s2.0-85061651018
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Fibers and Polymers. Vol 20, No.1 (2019)
Suggested Citation
Chuysinuan P., Pengsuk C., Lirdprapamongkol K., Techasakul S., Svasti J., Nooeaid P. Enhanced Structural Stability and Controlled Drug Release of Hydrophilic Antibiotic-Loaded Alginate/Soy Protein Isolate Core-Sheath Fibers for Tissue Engineering Applications. Fibers and Polymers. Vol 20, No.1 (2019). doi:10.1007/s12221-019-8753-y Retrieved from: https://hdl.handle.net/20.500.14740/5605
Abstract
Tissue engineering involves a multifunctional temporary matrix which regulates tissue regeneration through controlled drug release against infections. A nanofibrous core-sheath structured scaffold comprising a tetracycline-loaded alginate/soy protein isolate (TCH-Alg/SPI) as a core and polycaprolactone (PCL) as a sheath was developed using co-axial electrospinning. Coverage of hydrophobic PCL on TCH-Alg/SPI fibers enhanced their structural stability in aqueous solutions as unsheathed fibers rapidly decomposed and provided fast drug release. Core-sheath fibers exhibited an initial burst release at ~49 % after 6 h of immersion in phosphate-buffered saline (PBS) solution and the sustain release reached ~80 % of total loaded drug on day 14. Release characteristics of TCH-Alg/SPI fibers without PCL covering showed immediate drug release within 48 h. Core-sheath fibers investigated by disk diffusion exhibited antibacterial properties against Staphylococcus aureus and Escherichia coli. The non-toxicity of core-sheath fibers was confirmed by an indirect cytotoxicity test using human dermal fibroblasts which showed compatibility and high cell viability of up to 100 % in treated cells. TCH-Alg/SPI-PCL core-sheath fibers show promise as tissue engineering scaffolds which can act as temporary templates for tissue regeneration and exhibit antibiotic release functions against infections caused by pathogenic microorganisms. © 2019, The Korean Fiber Society, The Korea Science and Technology Center.
Subject(s)
Antibiotics
Cell culture
Cytotoxicity
Electrospinning
Escherichia coli
Fibers
Proteins
Scaffolds (biology)
Stability
Targeted drug delivery
Tissue
Tissue engineering
Tissue regeneration
Antibacterial properties
Coaxial electrospinning
Core sheaths
Drug release
Pathogenic microorganisms
Phosphate buffered saline solutions
Tissue engineering applications
Tissue engineering scaffold
Controlled drug delivery
Antibiotics
Cores
Engineering
Fibers
Proteins
Release
Stability
Tissue
Cell culture
Cytotoxicity
Electrospinning
Escherichia coli
Fibers
Proteins
Scaffolds (biology)
Stability
Targeted drug delivery
Tissue
Tissue engineering
Tissue regeneration
Antibacterial properties
Coaxial electrospinning
Core sheaths
Drug release
Pathogenic microorganisms
Phosphate buffered saline solutions
Tissue engineering applications
Tissue engineering scaffold
Controlled drug delivery
Antibiotics
Cores
Engineering
Fibers
Proteins
Release
Stability
Tissue