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CXCR4-targeted nanoparticles reduce cell viability, induce apoptosis and inhibit SDF-1α induced BT-549-Luc cell migration in vitro

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dc.contributor.authorChittasupho C.
dc.contributor.authorKewsuwan P.
dc.contributor.authorMurakami T.
dc.date.accessioned2021-04-05T03:23:07Z
dc.date.available2021-04-05T03:23:07Z
dc.date.issued2017
dc.date.issuedBE2560
dc.description.abstractBackground: CXCR4 possesses a critical role in several intracellular events such as chemotaxis, invasion and adhesion, which are associated with metastasis of cancer cell. Objective: In this study, CXCR4 targeted polymeric nanoparticle was developed for delivering cytotoxic drug and blocking the chemokine induced migration of cells expressing CXCR4. Method: A peptide which was a linear form of CXCR4 antagonist (LFC131) was attached to PLGA nanoparticles (LFC131-NPs) and PLGA nanoparticles encapsulating DOX (LFC131-DOX-NPs). The cellular binding and internalization of LFC131-DOX-NPs were investigated. Results: The binding and internalization of LFC131-DOX-NPs were higher and more rapidly compared to unconjugated NPs. LFC131-NPs blocked SDF-1α induced migration of BT-549-Luc cells. MTT assays demonstrated that LFC131-NPs and LFC131-DOX-NPs decreased cell viability in a dose dependent manner in 24, 72 and 120 h incubation. Conclusion: A treatment concept of blocking breast cancer cell migration from interaction with SDF- 1α by using LFC131-NPs and then attacking breast cancer cells with doxorubicin might increase the efficacy of current breast cancer treatment. © 2017 Bentham Science Publishers.
dc.format.mimetypeapplication/pdf
dc.identifier.citationCurrent Drug Delivery. Vol 14, No.8 (2017), p.1060-1070
dc.identifier.doi10.2174/1567201814666170216130448
dc.identifier.issn15672018
dc.identifier.other2-s2.0-85041060602
dc.identifier.urihttps://hdl.handle.net/20.500.14740/4744
dc.rights.holderScopus
dc.subject.otherChemokine
dc.subject.otherChemokine receptor CXCR4 antagonist
dc.subject.otherCytotoxic agent
dc.subject.otherDoxorubicin
dc.subject.otherLfc 131
dc.subject.otherNanoparticle
dc.subject.otherPolyglactin
dc.subject.otherStromal cell derived factor 1alpha
dc.subject.otherTyrosinylarginylarginine sodium iodide glycine
dc.subject.otherUnclassified drug
dc.subject.otherAntineoplastic antibiotic
dc.subject.otherChemokine receptor CXCR4
dc.subject.otherCXCL12 protein, human
dc.subject.otherCXCR4 protein, human
dc.subject.otherDoxorubicin
dc.subject.otherLactic acid
dc.subject.otherLigand
dc.subject.otherNanoparticle
dc.subject.otherOligopeptide
dc.subject.otherPolyglycolic acid
dc.subject.otherPolylactic acid-polyglycolic acid copolymer
dc.subject.otherStromal cell derived factor 1
dc.subject.otherApoptosis
dc.subject.otherArticle
dc.subject.otherBreast cancer cell line
dc.subject.otherBT 549 Luc cell line
dc.subject.otherCancer chemotherapy
dc.subject.otherCell migration
dc.subject.otherCell viability
dc.subject.otherComparative study
dc.subject.otherControlled study
dc.subject.otherDose response
dc.subject.otherDrug delivery system
dc.subject.otherDrug efficacy
dc.subject.otherDrug protein binding
dc.subject.otherHuman
dc.subject.otherHuman cell
dc.subject.otherIn vitro study
dc.subject.otherIncubation time
dc.subject.otherInternalization
dc.subject.otherMTT assay
dc.subject.otherPriority journal
dc.subject.otherAntagonists and inhibitors
dc.subject.otherApoptosis
dc.subject.otherBreast tumor
dc.subject.otherCell motion
dc.subject.otherCell proliferation
dc.subject.otherCell survival
dc.subject.otherChemistry
dc.subject.otherDrug effect
dc.subject.otherDrug screening
dc.subject.otherMetabolism
dc.subject.otherPathology
dc.subject.otherTumor cell culture
dc.subject.otherAntibiotics, Antineoplastic
dc.subject.otherApoptosis
dc.subject.otherBreast Neoplasms
dc.subject.otherCell Movement
dc.subject.otherCell Proliferation
dc.subject.otherCell Survival
dc.subject.otherChemokine CXCL12
dc.subject.otherDoxorubicin
dc.subject.otherDrug Screening Assays, Antitumor
dc.subject.otherHumans
dc.subject.otherLactic Acid
dc.subject.otherLigands
dc.subject.otherNanoparticles
dc.subject.otherOligopeptides
dc.subject.otherPolyglycolic Acid
dc.subject.otherReceptors, CXCR4
dc.subject.otherTumor Cells, Cultured
dc.titleCXCR4-targeted nanoparticles reduce cell viability, induce apoptosis and inhibit SDF-1α induced BT-549-Luc cell migration in vitro
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85041060602&doi=10.2174%2f1567201814666170216130448&partnerID=40&md5=cfe5aa097f88c55457c776568f239402

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