Publication: The randomized trials of 10% urea cream and 0.025% tretinoin cream in the treatment of acanthosis nigricans
1
0
Issued Date
2021
Resource Type
File Type
application/pdf
ISSN
9546634
Other identifier(s)
2-s2.0-85077886936
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Journal of Dermatological Treatment. Vol 32, No.7 (2021), p.837-842
Suggested Citation
Treesirichod A., Chaithirayanon S., Chaikul T., Chansakulporn S. The randomized trials of 10% urea cream and 0.025% tretinoin cream in the treatment of acanthosis nigricans. Journal of Dermatological Treatment. Vol 32, No.7 (2021), p.837-842. doi:10.1080/09546634.2019.1708855 Retrieved from: https://hdl.handle.net/20.500.14740/8129
Abstract
Background: Acanthosis nigricans is characterized as hyperpigmented skin and velvety surface on posterior and lateral folds of the neck and the intertriginous areas. This study aimed to assess the efficacy of topical 10% urea cream compared to 0.025% tretinoin cream in the treatment of acanthosis nigricans. Material and methods: This was an 8-week trial, double-blind, randomized, comparative study of topical 10% urea and 0.025% tretinoin for the treatment of the neck hyperpigmentation. The Mexameter MX18 was used for assessing treatment efficacy. The global evaluation scale was also used to evaluate the overall success rate at weeks 2, 4, and 8 of the study. Results: There was a statistically significant difference between 10% urea and 0.025% tretinoin in the treatment of acanthosis nigricans (p < 0.01). The efficacy of 10% urea and 0.025% tretinoin treatment shows 11.4 ± 5.7% and 20.1 ± 9.7% improvement, respectively. The treatment efficacy using the investigator's global evaluation found that 36.8% of participants treated with 10% urea and 63.2% of participants treated with 0.025% tretinoin had more than 75% skin improvement. Conclusion: Both medications significantly improved neck hyperpigmentation. However, the efficacy of 0.025% tretinoin was significantly better than 10% urea in the treatment of acanthosis nigricans. Clinical Trials Registry: TCTR20180703003. © 2020 Taylor & Francis Group, LLC.
Subject(s)
Retinoic acid
Urea
Keratolytic agent
Retinoic acid
Urea
Acanthosis nigricans
Adult
Article
Back
Clinical article
Comparative effectiveness
Controlled study
Cream
Double blind procedure
Drug efficacy
Drug tolerability
Erythema
Female
Human
Hyperpigmentation
Male
Neck
Randomized controlled trial
Skin burning sensation
Skin disease
Skin peeling (disease)
Skin pruritus
Randomized controlled trial (topic)
Acanthosis Nigricans
Humans
Keratolytic Agents
Randomized Controlled Trials as Topic
Tretinoin
Urea
Urea
Keratolytic agent
Retinoic acid
Urea
Acanthosis nigricans
Adult
Article
Back
Clinical article
Comparative effectiveness
Controlled study
Cream
Double blind procedure
Drug efficacy
Drug tolerability
Erythema
Female
Human
Hyperpigmentation
Male
Neck
Randomized controlled trial
Skin burning sensation
Skin disease
Skin peeling (disease)
Skin pruritus
Randomized controlled trial (topic)
Acanthosis Nigricans
Humans
Keratolytic Agents
Randomized Controlled Trials as Topic
Tretinoin
Urea