Publication: Biopolymer hydrogel scaffolds containing doxorubicin as a localized drug delivery system for inhibiting lung cancer cell proliferation
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Issued Date
2021
Resource Type
Language
eng
File Type
application/pdf
ISSN
20734360
Other identifier(s)
2-s2.0-85118320818
Rights Holder(s)
Scopus
Bibliographic Citation
Polymers. Vol 13, No.20 (2021)
Suggested Citation
Chittasupho C., Angklomklew J., Thongnopkoon T., Senavongse W., Jantrawut P., Ruksiriwanich W. Biopolymer hydrogel scaffolds containing doxorubicin as a localized drug delivery system for inhibiting lung cancer cell proliferation. Polymers. Vol 13, No.20 (2021). doi:10.3390/polym13203580 Retrieved from: https://hdl.handle.net/20.500.14740/8165
Abstract
A hydrogel scaffold is a localized drug delivery system that can maintain the therapeutic level of drug concentration at the tumor site. In this study, the biopolymer hydrogel scaffold encapsulating doxorubicin was fabricated from gelatin, sodium carboxymethyl cellulose, and gelatin/sodium carboxymethyl cellulose mixture using a lyophilization technique. The effects of a crosslinker on scaffold morphology and pore size were determined using scanning electron microscopy. The encapsulation efficiency and the release profile of doxorubicin from the hydrogel scaffolds were determined using UV-Vis spectrophotometry. The anti-proliferative effect of the scaffolds against the lung cancer cell line was investigated using an MTT assay. The results showed that scaffolds made from different types of natural polymer had different pore configurations and pore sizes. All scaffolds had high encapsulation efficiency and drug-controlled release profiles. The viability and proliferation of A549 cells, treated with gelatin, gelatin/SCMC, and SCMC scaffolds containing doxorubicin significantly decreased compared with control. These hydrogel scaffolds might provide a promising approach for developing a superior localized drug delivery system to kill lung cancer cells. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Subject(s)
Biological organs
Biomolecules
Biopolymers
Cell culture
Cell proliferation
Cellulose
Controlled drug delivery
Efficiency
Hydrogels
Scaffolds (biology)
Scanning electron microscopy
Sodium
Targeted drug delivery
A549 cells
Doxorubicin
Drug-delivery systems
Encapsulation efficiency
Freeze drying
Gelatin
Hydrogel scaffolds
Localised
Lung cancer cells
Sodium carboxymethyl cellulose
Pore size
Cellulose
Efficiency
Freeze Drying
Gelatin
Scanning Electron Microscopy
Sodium
Biomolecules
Biopolymers
Cell culture
Cell proliferation
Cellulose
Controlled drug delivery
Efficiency
Hydrogels
Scaffolds (biology)
Scanning electron microscopy
Sodium
Targeted drug delivery
A549 cells
Doxorubicin
Drug-delivery systems
Encapsulation efficiency
Freeze drying
Gelatin
Hydrogel scaffolds
Localised
Lung cancer cells
Sodium carboxymethyl cellulose
Pore size
Cellulose
Efficiency
Freeze Drying
Gelatin
Scanning Electron Microscopy
Sodium