Publication:
Application of a new chair-side method for the harvest of mesenchymal stem cells in a patient with nonunion of a fracture of the atrophic mandible - A case report

0
0

Issued Date

2009

Resource Type

Article

File Type

application/pdf

ISSN

10105182

DOI

10.1016/j.jcms.2008.11.002

Other identifier(s)

2-s2.0-61449183472

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Cranio-Maxillofacial Surgery. Vol 37, No.3 (2009), p.155-161

Suggested Citation

Wongchuensoontorn C., Liebehenschel N., Schwarz U., Schmelzeisen R., Gutwald R., Ellis Iii E., Sauerbier S. Application of a new chair-side method for the harvest of mesenchymal stem cells in a patient with nonunion of a fracture of the atrophic mandible - A case report. Journal of Cranio-Maxillofacial Surgery. Vol 37, No.3 (2009), p.155-161. doi:10.1016/j.jcms.2008.11.002 Retrieved from: https://hdl.handle.net/20.500.14740/7259

Title

Application of a new chair-side method for the harvest of mesenchymal stem cells in a patient with nonunion of a fracture of the atrophic mandible - A case report

Author(s)

Wongchuensoontorn C.
 Liebehenschel N.
 Schwarz U.
 Schmelzeisen R.
 Gutwald R.
 Ellis Iii E.
 Sauerbier S.

Abstract

Purpose: This case report describes a new clinical method for chair-side processing of a cell mixture which contains mesenchymal stem cells (MSCs) which was applied for the first time in the treatment of a nonunion of an atrophic fractured mandible. Methods: Bone marrow was aspirated and a corticocancellous bone graft was harvested from the iliac crest of a 56-year-old woman with medical comorbidities and a fracture of the atrophic mandible. The fracture was stabilized with a reconstruction bone plate, and mononuclear cells including MSCs were concentrated by centrifugation and applied in combination with a particulate bone transplant. A sample of the grafted cells was characterized by flow cytometric analysis and by their ability to differentiate into various cell types. Results: The fracture healed uneventfully. No complications occurred during the 4-month follow-up. Conclusion: Adding MSCs is a feasible alternative to enhance bone healing. This chair-side method requires little training and no cell laboratory support. © 2008 European Association for Cranio-Maxillofacial Surgery.

Subject(s)

Adult
 Article
 Bone graft
 Bone marrow biopsy
 Bone plate
 Bone radiography
 Cancellous bone
 Case report
 Cell differentiation
 Cell type
 Centrifugation
 Chair side method
 Comorbidity
 Cortical bone
 Curettage
 Dentist
 Denture
 Feasibility study
 Female
 Flow cytometry
 Follow up
 Fracture healing
 Fracture nonunion
 Hospital admission
 Human
 Human cell
 Iliac crest
 Laboratory test
 Mandible fracture
 Mandible reconstruction
 Maxillofacial surgery
 Mesenchymal stem cell
 Mononuclear cell
 Radiodiagnosis
 Sample
 Surgical training
 Surgical ward
 Adult Stem Cells
 Atrophy
 Bone Regeneration
 Female
 Fracture Healing
 Fractures, Ununited
 Humans
 Mandibular Fractures
 Mesenchymal Stem Cell Transplantation
 Mesenchymal Stem Cells
 Middle Aged
 Tissue and Organ Harvesting
 Treatment Outcome

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/7259

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By