Publication:
Bioactive constituents of the root bark of Artocarpus rigidus subsp. rigidus

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Issued Date

2006

Resource Type

Article

File Type

application/pdf

ISSN

92363

DOI

10.1248/cpb.54.1433

Other identifier(s)

2-s2.0-33749414443

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Chemical and Pharmaceutical Bulletin. Vol 54, No.10 (2006), p.1433-1436

Suggested Citation

Namdaung U., Aroonrerk N., Suksamrarn S., Danwisetkanjana K., Saenboonrueng J., Arjchomphu W., Suksamrarn A. Bioactive constituents of the root bark of Artocarpus rigidus subsp. rigidus. Chemical and Pharmaceutical Bulletin. Vol 54, No.10 (2006), p.1433-1436. doi:10.1248/cpb.54.1433 Retrieved from: https://hdl.handle.net/20.500.14740/5346

Title

Bioactive constituents of the root bark of Artocarpus rigidus subsp. rigidus

Author(s)

Namdaung U.
 Aroonrerk N.
 Suksamrarn S.
 Danwisetkanjana K.
 Saenboonrueng J.
 Arjchomphu W.
 Suksamrarn A.

Abstract

Investigation of the chemical constituents of the root bark of Artocarpus rigidus BLUME subsp. rigidus has led to the isolation of six, structurally diverse phenolic compounds. These included two new compounds with modified skeletons, the flavonoid 7-demethylartonol E (1) and the chromone artorigidusin (2), together with four known phenolic compounds, the xanthone artonol B (3), the flavonoid artonin F (4), the flavonoid cycloartobiloxanthone (5), and the xanthone artoindonesianin C (6). Compounds 1, 4, and 5 exhibited antiplasmodial activity against Plasmodium falciparum. All compounds showed antimycobacterial activity against Mycobacterium tuberculosis, with 4 being the most active compound (MIC 6.25 μg/ml). Compounds 5 and 6 were active against KB cells, whereas 2, 5, and 6 showed varying toxicity to BC cells. Compounds 1-3, 5, and 6 were active in the NCIH187 cytotoxicity assay, with 3 being the most active compound (IC50 1.26 μg/ml). © 2006 Pharmaceutical Society of Japan.

Subject(s)

7 demethylartonol e
 Artocarpus rigidus extract
 Artoindonesianin c
 Artonin F
 Artonol B
 Chromone artorigidusin
 Cycloartobiloxanthone
 Flavanoid
 Phenol derivative
 Plant extract
 Unclassified drug
 Xanthone derivative
 Antimicrobial activity
 Article
 Bark
 Breadfruit
 Carbon nuclear magnetic resonance
 Concentration response
 Controlled study
 Cytotoxicity
 Drug structure
 Human
 Human cell
 IC 50
 Minimum inhibitory concentration
 Mycobacterium tuberculosis
 Nonhuman
 Plant root
 Plasmodium falciparum
 Proton nuclear magnetic resonance
 Structure activity relation
 Animals
 Artocarpus
 Cell Line, Tumor
 Cell Proliferation
 Chromones
 Drug Screening Assays, Antitumor
 Flavonoids
 Humans
 Magnetic Resonance Spectroscopy
 Microbial Sensitivity Tests
 Molecular Structure
 Mycobacterium tuberculosis
 Phenols
 Plant Bark
 Plant Roots
 Plasmodium falciparum
 Reference Standards
 Sensitivity and Specificity
 Stereoisomerism
 Structure-Activity Relationship
 Xanthones

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URI

https://hdl.handle.net/20.500.14740/5346

Collections

Scopus: Year 1983-2021

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