Publication: Serum aminotransferases in Thai children with dengue infection
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Issued Date
2015
Resource Type
File Type
application/pdf
ISSN
20082142
DOI
Other identifier(s)
2-s2.0-84981717839
Rights Holder(s)
Scopus
Bibliographic Citation
Iranian Journal of Pediatrics. Vol 25, No.6 (2015)
Suggested Citation
Prommalikit O., Thisyakorn U., Thisyakorn C. Serum aminotransferases in Thai children with dengue infection. Iranian Journal of Pediatrics. Vol 25, No.6 (2015). doi:10.5812/ijp.443 Retrieved from: https://hdl.handle.net/20.500.14740/5995
Author(s)
Abstract
Background: Hepatic manifestations are one of the unusual manifestations of dengue infection. Objectives: We conducted this study in order to study the pattern of serum aminotransferases and sequential changes before and after shock in Thai children with dengue infection. Patients and Methods: Children who were clinically and serologically diagnosed as dengue infection and were admitted to King Chulalongkorn Memorial Hospital during a peroid of one year were enrolled. They were clinically classified into a non-shock group and a shock group. The majority of serum aminotransferases including aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were obtained within a week after the onset of fever and until 3 days after shock in the shock group. Student t-test and median in boxplot form were used for statistical analysis. Results: We enrolled 127 children with a mean age of 7.6 ± 3.6 years. The incidence of abnormal AST and ALT levels was 97.4% and 50.0% in the shock group, and 91.8% and 44.9% in the non-shock group respectively. 29% and 15.4% of the patients in shock group and only 10.2% and 4.1% in non-shock group had the respective AST and ALT levels > 200 U/L. Serum aminotransferase levels were significantly higher in the shock group when compared to the non-shock group. AST tended to increase starting from one day before shock and continued to increase within a few days whereas ALT was less likely to be affected. Conclusions: Elevated serum aminotransferases are a common finding in children with dengue infection and the levels of AST are higher than those of ALT. Patients with shock have significantly higher aminotransferase levels that increase up to 3 days after shock. © 2015, Growth & Development Research Center.
Subject(s)
Alanine aminotransferase
Aspartate aminotransferase
Adolescent
Alanine aminotransferase blood level
Article
Aspartate aminotransferase blood level
Child
Clinical examination
Controlled study
Dengue
Disease association
Disease classification
Disease severity
Female
Fever
Hospital admission
Human
Incidence
Major clinical study
Male
Onset age
Preschool child
School child
Serology
Shock
Statistical analysis
Student t test
Thai (people)
Aspartate aminotransferase
Adolescent
Alanine aminotransferase blood level
Article
Aspartate aminotransferase blood level
Child
Clinical examination
Controlled study
Dengue
Disease association
Disease classification
Disease severity
Female
Fever
Hospital admission
Human
Incidence
Major clinical study
Male
Onset age
Preschool child
School child
Serology
Shock
Statistical analysis
Student t test
Thai (people)