Publication: Influence of selected surfactants on the tackiness of acrylic polymer films
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Issued Date
2004
Resource Type
File Type
application/pdf
ISSN
3785173
Other identifier(s)
2-s2.0-8444238561
Rights Holder(s)
Scopus
Bibliographic Citation
International Journal of Pharmaceutics. Vol 287, (2004), p.27-37
Suggested Citation
Nimkulrat S., Suchiva K., Phinyocheep P., Puttipipatkhachorn S. Influence of selected surfactants on the tackiness of acrylic polymer films. International Journal of Pharmaceutics. Vol 287, (2004), p.27-37. doi:10.1016/j.ijpharm.2004.08.022 Retrieved from: https://hdl.handle.net/20.500.14740/6337
Abstract
Anti-tacking agents are always necessary in polymeric film coating formulations in order to prevent substrate agglomeration. The objective of this study was to investigate the abilities of certain nonionic surfactants in a group of sorbitan ester in reducing the tackiness of the films obtained from aqueous acrylic polymer dispersions (Eudragit ®), compared with those of talc and glyceryl monostearate (GMS). The results from the peel tests demonstrated that GMS, Span 60 and Span 40 could significantly reduce the tackiness of both Eudragit NE 30D and Eudragit RS 30D films. The mechanisms in reducing the film tackiness were investigated by analyzing the film compositions, using attenuated total internal reflectance infrared spectroscopy (ATR-IR) and optical microscopy. The storage modulus of the films was also examined. The results indicated that GMS, Span 60, and Span 40 could reduce the film tackiness by decreasing the polymer contents at the film surfaces, resulting in a notable reduction in the contact area of the polymers between the surfaces. The use of only 5% (w/w) of either GMS, Span 60 or Span 40 in the coating formulations is enough to prevent pellet agglomeration without adverse effects on film flexibility. The pellets coated with Eudragit RS 30D/RL 30D (9:1, w/w) did not exhibit any difference in the drug release profiles when either 100% (w/w) talc or 5% (w/w) GMS was used, whereas the formulations containing Span 60 or Span 40 gave a slightly faster release rate. © 2004 Elsevier B.V. All rights reserved.
Subject(s)
Acrylic acid derivative
Eudragit
Glycerol stearate
Lactose
Microcrystalline cellulose
Polymer
Povidone
Sorbitan ester
Sorbitan oleate
Sorbitan palmitate
Sorbitan stearate
Surfactant
Talc
Theophylline
Article
Chemical composition
Film
Infrared spectroscopy
Microscopy
Priority journal
Reflectometry
Surface property
Polymethacrylic Acids
Solubility
Surface-Active Agents
Eudragit
Glycerol stearate
Lactose
Microcrystalline cellulose
Polymer
Povidone
Sorbitan ester
Sorbitan oleate
Sorbitan palmitate
Sorbitan stearate
Surfactant
Talc
Theophylline
Article
Chemical composition
Film
Infrared spectroscopy
Microscopy
Priority journal
Reflectometry
Surface property
Polymethacrylic Acids
Solubility
Surface-Active Agents