Publication: Encapsulation of bioactive compounds (monocaprin and monolaurin) into polymeric nanoparticles
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Issued Date
2018
Resource Type
File Type
application/pdf
ISSN
2555476
Other identifier(s)
2-s2.0-85045332677
Rights Holder(s)
Scopus
Bibliographic Citation
Materials Science Forum. Vol 916 MSF, (2018), p.147-152
Suggested Citation
Kaewmanee P.C., Wongsatayanon B., Durand A. Encapsulation of bioactive compounds (monocaprin and monolaurin) into polymeric nanoparticles. Materials Science Forum. Vol 916 MSF, (2018), p.147-152. doi:10.4028/www.scientific.net/MSF.916.147 Retrieved from: https://hdl.handle.net/20.500.14740/3800
Author(s)
Abstract
The dextran-covered poly(lactic acid) (PLA) polymeric nanoparticles were prepared by a nanoprecipitation process for the encapsulation of monocaprin (MC) or monolaurin (ML). The concentration of PLA/MC or ML was varied to evaluate the best condition for preparation. The miscibility of various PLA/MC or ML blends was studied using differential scanning calorimetry. The result showed that at concentrations of 50/50 wt/wt, the PLA/ML blend was partly miscible and the nanoparticle suspension produced large amounts of macroscopic aggregates after nanoprecipitation. Conversely, the miscibility of PLA/MC blends progressively increased with increasing amounts of PLA. Therefore, the best concentration to encapsulate the MC was the PLA/MC 90/10 (wt/wt), according to the miscibility results. © 2018 Trans Tech Publications, Switzerland.