Publication: Cost-effectiveness analysis study of HPV testing as a primary cervical cancer screening in Thailand
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0
Issued Date
2017
Resource Type
File Type
application/pdf
ISSN
23525789
Other identifier(s)
2-s2.0-85030701631
Rights Holder(s)
Scopus
Bibliographic Citation
Gynecologic Oncology Reports. Vol 22, No. (2017), p.58-63
Suggested Citation
Termrungruanglert W., Khemapech N., Tantitamit T., Sangrajrang S., Havanond P., Laowahutanont P. Cost-effectiveness analysis study of HPV testing as a primary cervical cancer screening in Thailand. Gynecologic Oncology Reports. Vol 22, No. (2017), p.58-63. doi:10.1016/j.gore.2017.09.007 Retrieved from: https://hdl.handle.net/20.500.14740/4034
Abstract
Objectives The aim of this study is to compare the cost and benefit of four different cervical cancer screening strategies involving primary HPV 16/18 genotyping, hrHPV testing alone and cytology for detecting CIN2 +. Methods Economical analysis using Markov modeling approach to combine the epidemiological data from current population-based study of The National Cancer Institute of Thailand. A cohort of 100,000 hypothetical female population age 30–65 years was simulated in each strategy. The compared strategies are HPV 16/18 genotyping with reflexed cytology, hrHPV testing alone followed by colposcopy, Papanicolaou standard cytology and liquid based cytology followed by colposcopy. The interval of screening was 5 years' interval. The main outcomes were defined as a number of CIN2 + cases and cost per 100,000 women screening over 35 years. Results Model predictions indicated that, the most cost-effectiveness strategy is hrHPV testing alone by reducing cost and also increase CIN2 + detection rate. It identify an additional 130 cases and decrease cost by 46,950,840 THB (1,394,441 USD) per 100,000 women screened when compared to HPV 16/18 genotyping. Compared with cytology, hrHPV testing decrease cost by 51,279,781 THB (1,523,011 USD) and detected more 506 cases of CIN2 +. From sensitivity analysis, the cost of HPV testing, cost of colposcopy, incidence of HPV infection and sensitivity of cytology may affect the results. (1 USD = 33.67 Baht). Conclusion The results of this cost-effectiveness analysis support the full scale implementation of HPV testing as a primary cervical cancer screening in Thailand. © 2017 The Authors
Subject(s)
Adult
Article
Cancer screening
Colposcopy
Cost benefit analysis
Cost effectiveness analysis
Female
Human
Human papillomavirus DNA test
Human papillomavirus type 16
Human papillomavirus type 18
Incidence
Nonhuman
Papanicolaou test
Papillomavirus infection
Priority journal
Sensitivity and specificity
Simulation
Thailand
Uterine cervix cancer
Uterine cervix cytology
Article
Cancer screening
Colposcopy
Cost benefit analysis
Cost effectiveness analysis
Female
Human
Human papillomavirus DNA test
Human papillomavirus type 16
Human papillomavirus type 18
Incidence
Nonhuman
Papanicolaou test
Papillomavirus infection
Priority journal
Sensitivity and specificity
Simulation
Thailand
Uterine cervix cancer
Uterine cervix cytology