Publication: Efficacy of Adjunctive Zinc in Improving the Treatment Outcomes in Hospitalized Children with Pneumonia: A Randomized Controlled Trial
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Issued Date
2020
Resource Type
File Type
application/pdf
ISSN
14653664
Other identifier(s)
2-s2.0-85088849881
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Journal of tropical pediatrics. Vol 66, No.4 (2020), p.419-427
Suggested Citation
Rerksuppaphol L., Rerksuppaphol S. Efficacy of Adjunctive Zinc in Improving the Treatment Outcomes in Hospitalized Children with Pneumonia: A Randomized Controlled Trial. Journal of tropical pediatrics. Vol 66, No.4 (2020), p.419-427. doi:10.1093/tropej/fmz082 Retrieved from: https://hdl.handle.net/20.500.14740/4436
Author(s)
Abstract
BACKGROUND: The mortality rate of pneumonia is high, placing a huge burden on developing countries. Healthcare professionals use zinc as an adjunctive treatment for children with pneumonia; however, this contradicts with some published reports. Thus, this study aimed to assess the efficacy of zinc supplementation on the treatment outcomes of pneumonia. METHODS: A randomized, double-blind, placebo-controlled trial was conducted on hospitalized children with pneumonia. The children randomly received either zinc bis-glycinate (15 mg elemental zinc) or placebo, twice per day. The primary outcome was the resolution time of pneumonia, and the secondary outcomes were the duration of hospitalization and the recovery times of each clinical symptom. RESULTS: Out of the 91 children, 65 (71.4%) were males. The resolution period of clinical pneumonia was significantly shorter in the zinc group than the placebo group (48 and 72 h, respectively; hazard ratio = 0.585, 95% confidence interval 0.377-0.908). Similarly, the hospitalization period and the resolution period of fever were shorter in the zinc group [96 and 144 h (p = 0.008), and 24 and 42 h (p = 0.002), respectively]. Children receiving zinc needed a median of 28 h to reach the normal level of oxygen saturation compared to 48 h required by children under placebo (p = 0.014). CONCLUSION: Zinc supplementation enhanced the treatment outcomes of pneumonia, by reducing the resolution period of pneumonia and normalizing oxygen levels and body temperature. The length of hospital stay for children receiving zinc was shorter than those receiving placebo. © The Author(s) [2019]. Published by Oxford University Press. All rights reserved. For permissions, please email: [email protected].
Subject(s)
Antiinfective agent
Zinc
Child
Complication
Controlled study
Dietary supplement
Double blind procedure
Female
Fever
Hospital patient
Human
Infant
Length of stay
Male
Pneumonia
Preschool child
Randomized controlled trial
Treatment outcome
Anti-Bacterial Agents
Child
Child, Preschool
Dietary Supplements
Double-Blind Method
Female
Fever
Humans
Infant
Inpatients
Length of Stay
Male
Pneumonia
Treatment Outcome
Zinc
Zinc
Child
Complication
Controlled study
Dietary supplement
Double blind procedure
Female
Fever
Hospital patient
Human
Infant
Length of stay
Male
Pneumonia
Preschool child
Randomized controlled trial
Treatment outcome
Anti-Bacterial Agents
Child
Child, Preschool
Dietary Supplements
Double-Blind Method
Female
Fever
Humans
Infant
Inpatients
Length of Stay
Male
Pneumonia
Treatment Outcome
Zinc