Publication:
The Effectiveness of Nortriptyline and Tolerability of Side Effects in Neurogenic Cough Patients

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Issued Date

2021

Resource Type

Article

Language

eng

File Type

application/pdf

ISSN

34894

DOI

10.1177/0003489420970234

Other identifier(s)

2-s2.0-85096324541

Rights Holder(s)

Scopus

Bibliographic Citation

Annals of Otology, Rhinology and Laryngology. Vol 130, No.7 (2021), p.781-787

Suggested Citation

Song S.A., Choksawad K., Franco R.A., Jr. The Effectiveness of Nortriptyline and Tolerability of Side Effects in Neurogenic Cough Patients. Annals of Otology, Rhinology and Laryngology. Vol 130, No.7 (2021), p.781-787. doi:10.1177/0003489420970234 Retrieved from: https://hdl.handle.net/20.500.14740/6909

Title

The Effectiveness of Nortriptyline and Tolerability of Side Effects in Neurogenic Cough Patients

Author(s)

Song S.A.
 Choksawad K.
 Franco R.A.
 Jr.

Abstract

Objective: To determine the effectiveness of nortriptyline and tolerability of side effects in the treatment of neurogenic cough. Secondary goal is to evaluate the association between laryngeal asymmetry and clinical response to nortriptyline. Study Design: Retrospective case series. Materials and Methods: Consecutive patients diagnosed with neurogenic cough at a quaternary care specialty hospital from 2001 to 2020 were identified. Subjects <18 years old, not treated with nortriptyline, did not have a nasolaryngoscopic examination and were lost to follow-up were excluded. Charts were reviewed for demographic information, clinical history, nasolaryngoscopic findings, medication dosage, side effects, and follow-up time. Results: Forty-two patients met inclusion and exclusion criteria, 7 males and 35 females with an average age of 56.5 (±13.1) years. There were 26/36 (72.2%) responders and 10/36 (27.8%) non-responders; 6 patients stopped nortriptyline due to side effects and were not included in the response comparison. Laryngeal asymmetry was present in 36/42 (85.7%) patients. No factors related to laryngeal asymmetry were significantly different between responders and non-responders. Medication tolerance was observed in 3/42 (7.1%) patients. Side effects were reported in 16/42 (38.1%) patients. The most common side effects were sedation 9/42 (21.4%) and xerostomia 3/42 (7.1%). Conclusion: Nortriptyline is effective for treating neurogenic cough with 72% of patients reporting improvement in cough. Evidence of laryngeal asymmetry was not associated with better treatment response. Although 38% experienced side effects, the majority of patients continued nortriptyline despite side effects. Level of Evidence: 4. © The Author(s) 2020.

Subject(s)

Nortriptyline
 Nortriptyline
 Adult
 Anxiety
 Article
 Body weight gain
 Case study
 Chronic cough
 Clinical article
 Clinical outcome
 Controlled study
 Demography
 Dizziness
 Drug dose increase
 Drug dose regimen
 Drug dose titration
 Drug efficacy
 Drug tolerability
 Drug withdrawal
 Evening dosage
 Female
 Follow up
 Gastrointestinal symptom
 Human
 Laryngoscopy
 Larynx
 Male
 Maximum tolerated dose
 Medical history
 Medical record review
 Middle aged
 Neurogenic cough
 Neurogenic cough
 Priority journal
 Pruritus
 Retrospective study
 Side effect
 Somnolence
 Treatment response
 Treatment response time
 Upper respiratory tract infection
 Xerostomia
 Aged
 Complication
 Coughing
 Neurologic disease
 Pathology
 Treatment outcome
 Adult
 Aged
 Cough
 Female
 Humans
 Larynx
 Male
 Middle Aged
 Nervous System Diseases
 Nortriptyline
 Retrospective Studies
 Treatment Outcome

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URI

https://hdl.handle.net/20.500.14740/6909

Collections

Scopus: Year 1983-2021

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