Publication:
Steroid responsiveness in adults with primary immune thrombocytopenia: A single center study

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Issued Date

2017

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-85074982970

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 100, No.10 (2017), p.S69-S77

Suggested Citation

Makruasi N., Phukiat N. Steroid responsiveness in adults with primary immune thrombocytopenia: A single center study. Journal of the Medical Association of Thailand. Vol 100, No.10 (2017), p.S69-S77. Retrieved from: https://hdl.handle.net/20.500.14740/4389

Title

Steroid responsiveness in adults with primary immune thrombocytopenia: A single center study

Author(s)

Makruasi N.
 Phukiat N.

Abstract

Background: Primary immune thrombocytopenia (ITP) is a common life-threatening condition of a benign hematologic disease. The standard treatment is corticosteroids. Dismal study to determine response between groups of steroids in Thailand. Assessing the steroid response of each form of steroid may improve the outcome of ITP. Objective: The objective is to determine the results of steroid administration in newly diagnosed or patients with relapsed primary ITP by comparing the response between prednisolone and dexamethasone. Material and Method: The study is a retrospective, descriptive study. We have reviewed medical records of thirty-nine primary ITP patients taken between the years of 2007 to 2014 at the HRH Princess Maha Chakri Sirindhorn Medical Center. Data collections were of the personal demographics, disease characteristics, treatments, and the outcomes of treatments. The statistical analyses include the percentages, mean scores, and standard deviation. The Chi-square and Fisher’s exact correlation were used to identify the categorical variables and to assess between the independent variables and outcomes. The ANOVA test confirmed the continuous variables. A p-value <0.05 was considered statistically significant. Results: Data from the 39 patients have shown that the median age was 40.6 years (15 to 85 years). The female gender was a predominant factor. Twenty-seven patients (69.2%) were newly diagnosed ITP. Most of the patients (84.62%) experienced a history of bleeding in which skin bleeding was the major type (60.6%). There were 15 (38.5%) and 24 (61.5%) patients treated with prednisolone and dexamethasone, respectively. The history of bleeding (p = 0.02) and low platelet counts prior to treatment (p=0.04) were seen predominantly in the dexamethasone group when compared to the prednisolone group. The accumulation of levels of steroids were found to be higher in the dexamethasone group during the first week (p = 0.00), but no differences were seen between 2 and 4 weeks of treatment (p = 0.20, 0.14, and 0.19). The initial response to therapy in the dexamethasone group was 77.2%, and 88.9% in prednisolone group. However, the 1 to 4 week treatment outcomes were not different between either of the groups. Gender, age (less than 18 years), diagnoses of being a new case or a relapsed case and the type of corticosteroid have shown no effects on the outcomes of the treatments. Conclusion: Dexamethasone and prednisolone provide equal clinical outcomes for the patients with ITP during the first month of the therapeutic regimens. © 2017 Medical Association of Thailand. All rights reserved.

Subject(s)

Azathioprine
 Colchicine
 Cyclophosphamide
 Dexamethasone
 Immunoglobulin
 Prednisolone
 Steroid
 Adolescent
 Adult
 Aged
 Article
 Blood cell count
 Clinical article
 Clinical outcome
 Controlled study
 Descriptive research
 Drug dose reduction
 Drug substitution
 Female
 Human
 Idiopathic thrombocytopenic purpura
 Immune response
 Male
 Platelet count
 Retrospective study
 Skin bleeding
 Thrombocytopenia
 Treatment outcome
 Very elderly

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URI

https://hdl.handle.net/20.500.14740/4389

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Scopus: Year 1983-2021

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