Publication:
The use of the stabilization period in electroconvulsive therapy research in schizophrenia : II. Implementation

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Issued Date

1999

Resource Type

Article

File Type

application/pdf

ISSN

1252208

Other identifier(s)

2-s2.0-0033144887

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the Medical Association of Thailand. Vol 82, No.6 (1999), p.558-567

Suggested Citation

Chanpattana W., Kirdcharoen N., Techakasem P., Chakrabhand M.L.S., Tuntirungsee Y., Prasertsuk Y. The use of the stabilization period in electroconvulsive therapy research in schizophrenia : II. Implementation. Journal of the Medical Association of Thailand. Vol 82, No.6 (1999), p.558-567. Retrieved from: https://hdl.handle.net/20.500.14740/7139

Title

The use of the stabilization period in electroconvulsive therapy research in schizophrenia : II. Implementation

Author(s)

Chanpattana W.
 Kirdcharoen N.
 Techakasem P.
 Chakrabhand M.L.S.
 Tuntirungsee Y.
 Prasertsuk Y.

Abstract

Background: Electroconvulsive therapy (ECT) has been used to treat schizophrenia since its inception in 1938. Nonetheless, there has never been a research study documenting the efficacy of ECT in schizophrenia. All ECT studies suffered unexceptable methodological flaws. The authors hypothesized the 3-week stabilization period as: 1) a screening method for ECT responders, 2) a procedure for obtaining a homogeneous group of patients ideally suitable for the continuation treatment study, and, 3) as a part of our relapse criteria. Method: One hundred and fourteen schizophrenic patients received acute Phase I treatment with bilateral ECT and flupenthixol (12-24 mg/d). After the first sign of clinical improvement, all patients had to pass a 3-week stabilization period during which their clinical improvement had to be sustained. The patients had to receive at least 20 ECT treatments before being considered unresponsive to ECT. Fifty one patients enrolled in the continuation (Phase II) treatment study, and were randomized to the 3 treatment groups. Results: In Phase I study, 58 patients were ECT responders by our criteria, 43 were nonresponders, and 13 were drop-outs. Forty five patients either relapsed or completed the Phase II study, while 6 patients dropped out. By our relapse criteria, 6 of 15 relapsed in the combined C-ECT and flupenthixol group, and 14 of 15 relapsed in both the group treated with C-ECT alone or flupenthixol alone. The use of the stabilization period in this study could complete all three objectives previously described. Conclusions: The use of the stabilization period is very useful in ECT research in schizophrenia.

Subject(s)

Adolescent
 Adult
 Article
 Clinical protocol
 Clinical trial
 Controlled clinical trial
 Controlled study
 Electroconvulsive therapy
 Female
 Human
 Male
 Methodology
 Middle aged
 Multimodality cancer therapy
 Phase 1 clinical trial
 Phase 2 clinical trial
 Prospective study
 Randomized controlled trial
 Schizophrenia
 Single blind procedure
 Standard
 Treatment outcome
 Adolescent
 Adult
 Clinical Protocols
 Combined Modality Therapy
 Electroconvulsive Therapy
 Female
 Humans
 Male
 Middle Aged
 Prospective Studies
 Schizophrenia
 Single-Blind Method
 Treatment Outcome

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URI

https://hdl.handle.net/20.500.14740/7139

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Scopus: Year 1983-2021

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