Publication:
Curcumin extract for prevention of type 2 diabetes

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Issued Date

2012

Resource Type

Article

File Type

application/pdf

ISSN

1495992

DOI

10.2337/dc12-0116

Other identifier(s)

2-s2.0-84868150021

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Diabetes Care. Vol 35, No.11 (2012), p.2121-2127

Suggested Citation

Chuengsamarn S., Rattanamongkolgul S., Luechapudiporn R., Phisalaphong C., Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. Vol 35, No.11 (2012), p.2121-2127. doi:10.2337/dc12-0116 Retrieved from: https://hdl.handle.net/20.500.14740/6927

Title

Curcumin extract for prevention of type 2 diabetes

Author(s)

Chuengsamarn S.
 Rattanamongkolgul S.
 Luechapudiporn R.
 Phisalaphong C.
 Jirawatnotai S.

Abstract

OBJECTIVE - To assess the efficacy of curcumin in delaying development of type 2 diabetes mellitus (T2DM) in the prediabetic population. RESEARCH DESIGN AND METHODS - This randomized, double-blinded, placebo-controlled trial included subjects (n = 240) with criteria of prediabetes. All subjects were randomly assigned to receive either curcumin or placebo capsules for 9months. To assess the T2DM progression after curcumin treatments and to determine the number of subjects progressing to T2DM, changes in β-cell functions (homeostasis model assessment [HOMA]-β, C-peptide, and proinsulin/insulin), insulin resistance (HOMA-IR), anti-inflammatory cytokine (adiponectin), and other parameters were monitored at the baseline and at 3-, 6-, and 9-month visits during the course of intervention. RESULTS - After 9 months of treatment, 16.4% of subjects in the placebo group were diagnosed with T2DM, whereas none were diagnosed with T2DM in the curcumin-treated group. In addition, the curcumin-treated group showed a better overall function of β-cells, with higher HOMA-β (61.58 vs. 48.72; P < 0.01) and lower C-peptide (1.7 vs. 2.17; P < 0.05). The curcumin-treated group showed a lower level of HOMA-IR (3.22 vs. 4.04; P < 0.001) and higher adiponectin (22.46 vs. 18.45; P < 0.05) when compared with the placebo group. CONCLUSIONS - A 9-month curcumin intervention in a prediabetic population significantly lowered the number of prediabetic individuals who eventually developed T2DM. In addition, the curcumin treatment appeared to improve overall function of β-cells, with very minor adverse effects. Therefore, this study demonstrated that the curcumin intervention in a prediabetic population may be beneficial. © 2012 by the American Diabetes Association.

Subject(s)

Adiponectin
 C peptide
 Curcumin
 Insulin
 Placebo
 Proinsulin
 Adult
 Article
 Cell function
 Constipation
 Controlled study
 Double blind procedure
 Drug efficacy
 Drug response
 Drug safety
 Female
 Human
 Hypoglycemia
 Impaired glucose tolerance
 Insulin resistance
 Major clinical study
 Male
 Non insulin dependent diabetes mellitus
 Pancreas islet beta cell
 Patient compliance
 Pruritus
 Randomized controlled trial
 Side effect
 Treatment outcome
 Vertigo
 Waist circumference
 Weight reduction
 Curcumin
 Diabetes Mellitus, Type 2
 Double-Blind Method
 Female
 Humans
 Male
 Middle Aged
 Plant Extracts
 Prediabetic State
 Treatment Outcome

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URI

https://hdl.handle.net/20.500.14740/6927

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Scopus: Year 1983-2021

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