Publication:
RUNX1 Regulates Migration, Invasion, and Angiogenesis via p38 MAPK Pathway in Human Glioblastoma

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dc.contributor.authorSangpairoj K.
dc.contributor.authorVivithanaporn P.
dc.contributor.authorApisawetakan S.
dc.contributor.authorChongthammakun S.
dc.contributor.authorSobhon P.
dc.contributor.authorChaithirayanon K.
dc.date.accessioned2021-04-05T03:22:03Z
dc.date.available2021-04-05T03:22:03Z
dc.date.issued2017
dc.date.issuedBE2560
dc.description.abstractRunt-related transcription factor 1 (RUNX1) is essential for the establishment of fetal and adult hematopoiesis and neuronal development. Aberrant expression of RUNX1 led to proliferation and metastasis of several cancers. The aim of the present study was to investigate the role of RUNX1 in migration, invasion, and angiogenesis of human glioblastoma using IL-1β-treated U-87 MG human glioblastoma cells as a model. IL-1β at 10 ng/ml stimulated translocation of RUNX1 into the nucleus with increased expressions of RUNX1, MMP-1, MMP-2, MMP-9, MMP-19, and VEGFA in U-87 MG cells. In addition, silencing of RUNX1 gene significantly suppressed U-87 MG cell migration and invasion abilities. Moreover, knockdown of RUNX1 mRNA in U-87 MG cells reduced the tube formation of human umbilical vein endothelial cells. Further investigation revealed that IL-1β-induced RUNX1 expression might be mediated via the p38 mitogen-activated protein kinase (MAPK) signaling molecule for the expression of these invasion- and angiogenic-related molecules. Together with an inhibitor of p38 MAPK (SB203580) could decrease RUNX1 mRNA expression. Thus, RUNX1 may be one of the putative molecular targeted therapies against glioma metastasis and angiogenesis through the activation of p38 MAPK signaling pathway. © 2016, Springer Science+Business Media New York.
dc.format.mimetypeapplication/pdf
dc.identifier.citationCellular and Molecular Neurobiology. Vol 37, No.7 (2017), p.1243-1255
dc.identifier.doi10.1007/s10571-016-0456-y
dc.identifier.issn2724340
dc.identifier.other2-s2.0-85007236818
dc.identifier.urihttps://hdl.handle.net/20.500.14740/4073
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.otherGelatinase A
dc.subject.otherGelatinase B
dc.subject.otherInterleukin 1beta
dc.subject.otherInterstitial collagenase
dc.subject.otherMitogen activated protein kinase 14
dc.subject.otherSmall interfering RNA
dc.subject.otherTranscription factor RUNX1
dc.subject.otherVasculotropin A
dc.subject.otherMitogen activated protein kinase p38
dc.subject.otherRUNX1 protein, human
dc.subject.otherTranscription factor RUNX1
dc.subject.otherAngiogenesis
dc.subject.otherArticle
dc.subject.otherCarcinogenesis
dc.subject.otherCell invasion
dc.subject.otherCell migration
dc.subject.otherControlled study
dc.subject.otherEnzyme activation
dc.subject.otherGene expression
dc.subject.otherGene silencing
dc.subject.otherGlioblastoma
dc.subject.otherGlioblastoma cell line
dc.subject.otherHuman
dc.subject.otherHuman cell
dc.subject.otherIn vitro study
dc.subject.otherMAPK signaling
dc.subject.otherPriority journal
dc.subject.otherUmbilical vein endothelial cell
dc.subject.otherBrain tumor
dc.subject.otherCell motion
dc.subject.otherGlioblastoma
dc.subject.otherMetabolism
dc.subject.otherNeovascularization (pathology)
dc.subject.otherPathology
dc.subject.otherPhysiology
dc.subject.otherTumor cell line
dc.subject.otherTumor invasion
dc.subject.otherBrain Neoplasms
dc.subject.otherCell Line, Tumor
dc.subject.otherCell Movement
dc.subject.otherCore Binding Factor Alpha 2 Subunit
dc.subject.otherGlioblastoma
dc.subject.otherHuman Umbilical Vein Endothelial Cells
dc.subject.otherHumans
dc.subject.otherMAP Kinase Signaling System
dc.subject.otherNeoplasm Invasiveness
dc.subject.otherNeovascularization, Pathologic
dc.subject.otherP38 Mitogen-Activated Protein Kinases
dc.titleRUNX1 Regulates Migration, Invasion, and Angiogenesis via p38 MAPK Pathway in Human Glioblastoma
dc.typeArticle
dspace.entity.typePublication
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