Publication:
Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice

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Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

22211691

DOI

10.4103/2221-1691.250859

Other identifier(s)

2-s2.0-85061075624

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Asian Pacific Journal of Tropical Biomedicine. Vol 9, No.2 (2019), p.80-84

Suggested Citation

Nanna U., Naowaboot J., Chularojmontri L., Tingpej P., Wattanapitayakul S. Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice. Asian Pacific Journal of Tropical Biomedicine. Vol 9, No.2 (2019), p.80-84. doi:10.4103/2221-1691.250859 Retrieved from: https://hdl.handle.net/20.500.14740/5480

Title

Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice

Author(s)

Nanna U.
 Naowaboot J.
 Chularojmontri L.
 Tingpej P.
 Wattanapitayakul S.

Abstract

Objective: To examine the effect of Brassica oleracea extract (BO) on impaired glucose and lipid homeostasis in high-fat diet (HFD)-induced obese mice. Methods: Obesity of ICR mice was induced by feeding a HFD (45 kcal% lard fat) for 16 weeks. During the last 8 weeks of study period, obese mice were additionally administered with BO (100 and 200 mg/kg/day). The metabolic parameters were determined. The gene expressions of hepatic lipogenesis were also studied. Results: After 8 weeks of treatment, BO (100 and 200 mg/kg) significantly reduced hyperglycemia and improved insulin sensitivity (P < 0.05). The serum lipid (total cholesterol, triglyceride, and non-esterified fatty acid) and hepatic triglyceride and non-esterified fatty acid were decreased (P < 0.05). The levels of insulin and leptin in serum were also decreased (P < 0.05). Moreover, the expressions of hepatic lipogenic genes including sterol regulatory element-binding protein 1c, fatty acid synthase, and acetyl-CoA carboxylase were decreased by BO treatment (P < 0.05). Conclusions: These results suggest that BO is a new therapeutic agent for improving the homeostasis of glucose and lipid in HFD-induced obese mice probably by suppression of lipogenic genes in liver tissue. © 2019 Asian Pacific Journal of Tropical Biomedicine Produced by Wolters Kluwer-Medknow.

Subject(s)

Acetyl coenzyme A carboxylase
 Antidiabetic agent
 Brassica oleracea extract
 Cholesterol
 Fatty acid
 Fatty acid synthase
 Glucose
 Insulin
 Leptin
 Plant extract
 Sterol regulatory element binding protein 1c
 Triacylglycerol
 Unclassified drug
 Animal experiment
 Animal model
 Animal tissue
 Article
 Brassica oleracea
 Cholesterol blood level
 Controlled study
 Diet induced obesity
 Fatty acid blood level
 Gene expression
 Glucose homeostasis
 Hormone blood level
 Impaired glucose tolerance
 Insulin blood level
 Insulin sensitivity
 Lipid blood level
 Lipid diet
 Lipid homeostasis
 Lipogenesis
 Male
 Mouse
 Nonhuman
 Priority journal
 Treatment duration
 Triacylglycerol blood level

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URI

https://hdl.handle.net/20.500.14740/5480

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Scopus: Year 1983-2021

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