Publication:
Lactobacillus acidophilus and Bifidobacterium bifidum stored at ambient temperature are effective in the treatment of acute diarrhoea

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Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

2724936

DOI

10.1179/146532810X12858955921159

Other identifier(s)

2-s2.0-78649677081

Rights Holder(s)

Scopus

Bibliographic Citation

Annals of Tropical Paediatrics. Vol 30, No.4 (2010), p.299-304

Suggested Citation

Rerksuppaphol S., Rerksuppaphol L. Lactobacillus acidophilus and Bifidobacterium bifidum stored at ambient temperature are effective in the treatment of acute diarrhoea. Annals of Tropical Paediatrics. Vol 30, No.4 (2010), p.299-304. doi:10.1179/146532810X12858955921159 Retrieved from: https://hdl.handle.net/20.500.14740/7491

Title

Lactobacillus acidophilus and Bifidobacterium bifidum stored at ambient temperature are effective in the treatment of acute diarrhoea

Author(s)

Rerksuppaphol S.
 Rerksuppaphol L.

Abstract

Introduction: Probiotics have demonstrated potential to reduce duration of diarrhoea and frequency of watery stools. Probiotics such as Lactobacillus acidophilus and Bifidobacterium bifidum (Infloran®) are usually maintained at a storage temperature of 4°C which is generally not feasible in tropical or sub-tropical countries. Aim: The efficacy of Infloran® for treatment of acute diarrhoea when stored at 28-32°C (room temperature) was evaluated. Methods: This was a double-blind, randomised study of infants and children aged 2 months to 7 years with acute diarrhoea. Patients were randomly assigned to receive Infloran® stored at 4°C, at room temperature, or to a placebo group. Duration of diarrhoea was a primary outcome, while the number of stools, hospital stay and requirement for rehydration fluid were secondary outcomes. Results: Probiotics shortened duration of diarrhoea (34.1 and 34.8 hrs when stored either at 4°C or at room temperature, respectively, and 58 hrs with placebo, p<0.01) and reduced the number of stools (7.3 and 8 vs 15.9 with placebo, p<0.01). Conclusion: Administration of probiotics is beneficial as additional treatment of acute diarrhoea and efficacy is not affected by storage temperature. © 2010 W. S. Maney & Son Ltd.

Subject(s)

Infloran
 Placebo
 Probiotic agent
 Unclassified drug
 Absence of side effects
 Acute diarrhea
 Article
 Bifidobacterium bifidum
 Child
 Clinical trial
 Controlled clinical trial
 Controlled study
 Disease duration
 Double blind procedure
 Drug efficacy
 Drug storage
 Environmental temperature
 Feces analysis
 Female
 Human
 Infant
 Lactobacillus acidophilus
 Length of stay
 Major clinical study
 Male
 Preschool child
 Randomized controlled trial
 Rehydration
 School child
 Acute Disease
 Bifidobacterium
 Child
 Child, Preschool
 Diarrhea
 Diarrhea, Infantile
 Double-Blind Method
 Feces
 Female
 Humans
 Infant
 Lactobacillus acidophilus
 Length of Stay
 Male
 Probiotics
 Refrigeration
 Temperature
 Time Factors
 Treatment Outcome

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URI

https://hdl.handle.net/20.500.14740/7491

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Scopus: Year 1983-2021

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