Publication:
Changes in oral cytokeratin expression in HIV-infected subjects with long-term use of HAART

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Issued Date

2012

Resource Type

Article

File Type

application/pdf

ISSN

1354523X

DOI

10.1111/j.1601-0825.2012.01947.x

Other identifier(s)

2-s2.0-84866864081

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Oral Diseases. Vol 18, No.8 (2012), p.793-801

Suggested Citation

Nittayananta W., Mitarnun W., Talungchit S., Sriplung H. Changes in oral cytokeratin expression in HIV-infected subjects with long-term use of HAART. Oral Diseases. Vol 18, No.8 (2012), p.793-801. doi:10.1111/j.1601-0825.2012.01947.x Retrieved from: https://hdl.handle.net/20.500.14740/6937

Title

Changes in oral cytokeratin expression in HIV-infected subjects with long-term use of HAART

Author(s)

Nittayananta W.
 Mitarnun W.
 Talungchit S.
 Sriplung H.

Abstract

Objectives: The objectives of this study were to determine (i) the expression of oral cytokeratins (CKs) among human immunodeficiency virus (HIV)-infected subjects compared with non-HIV controls, (ii) the oral CK expression in the subjects with highly active antiretroviral therapy (HAART) compared with those without HAART, and (iii) factors associated with the expression of oral CKs. Materials and methods: Oral tissues from buccal mucosa were obtained by punched biopsy in HIV-infected subjects with and without HAART, and non-HIV individuals. The samples were processed for immunohistochemical studies of CK1, CK13, CK14, CK16, and involucrin. The staining intensity was scored and recorded. Logistic regression analysis and multi-way ANOVA test were performed. Results: The expression of CK13, CK14, and CK16 was found to be significantly different between HIV-infected subjects and non-HIV individuals (P<0.05). The expression of those CKs was also significantly different between those who were and were not on HAART (P<0.05). No significant difference between the groups was observed regarding CK1 and involucrin. Conclusions: Oral epithelial cell differentiation as marked by the CK expression is affected by HIV infection and use of HAART. CKs may be the useful biomarkers to identify HIV-infected subjects who are at risk of malignant transformation of the oral mucosa because of HIV infection and HAART. © 2012 John Wiley & Sons A/S.

Subject(s)

Cytokeratin 1
 Cytokeratin 13
 Cytokeratin 14
 Cytokeratin 16
 Involucrin
 Adult
 Article
 Cheek mucosa
 Comparative study
 Controlled study
 Cross-sectional study
 Differentiation
 Epithelium cell
 Female
 Highly active antiretroviral therapy
 Human
 Human immunodeficiency virus infection
 Human tissue
 Major clinical study
 Male
 Mouth
 Mouth mucosa
 Predictive value
 Priority journal
 Protein analysis
 Protein expression
 Punch biopsy
 3,3'-Diaminobenzidine
 Adult
 Alcohol Drinking
 Antiretroviral Therapy, Highly Active
 Biopsy, Needle
 CD4 Lymphocyte Count
 Chromogenic Compounds
 Cross-Sectional Studies
 Epithelial Cells
 Female
 HIV
 HIV Infections
 HIV Seropositivity
 Humans
 Keratin-1
 Keratin-13
 Keratin-14
 Keratin-16
 Keratins
 Male
 Middle Aged
 Mouth Mucosa
 Protein Precursors
 Smoking
 Viral Load
 Young Adult

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URI

https://hdl.handle.net/20.500.14740/6937

Collections

Scopus: Year 1983-2021

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