Publication: Regulatory T cells and Foxp3 levels in naïve and highly active antiretroviral therapy given HIV-1 infected patients
1
0
Issued Date
2011
Resource Type
File Type
application/pdf
ISSN
9702067
Other identifier(s)
2-s2.0-81455139289
Rights Holder(s)
Scopus
Bibliographic Citation
Biomedicine. Vol 31, No.3 (2011), p.296-301
Suggested Citation
Srisurapanon S., Sukwit S., Chuenchitra T., Villaroel A., Horthongkham N., Sutthent R. Regulatory T cells and Foxp3 levels in naïve and highly active antiretroviral therapy given HIV-1 infected patients. Biomedicine. Vol 31, No.3 (2011), p.296-301. Retrieved from: https://hdl.handle.net/20.500.14740/7288
Abstract
Background & Objectives: The frequency and expression levels of FoxP3 in regulatory T-cells (T-regs) from advanced-stage HIV-infected patients are controversial. Thus, the aims of this study were to compare these parameters of T-regs from HIV infected patients and from healthy controls. Methods: T-reg population and expression levels of FoxP3 were assessed from 43 HIV-infected individuals and 12 healthy controls by using FACs flow cytometry. Results: Minor decrease in frequencies of T-regs was found in both infected groups (naïve and treated) compared with those from healthy controls (p=0.02, p=0.01, respectively). In contrast, a significantly increase in the ratios of T-regs:CD4+cells from HIV-infected patients was observed (p=0.001). In addition, FoxP3 expression levels in both treated and untreated HIV-1 infected patients were significantly higher than those in healthy controls (p<0.001 and 0.01 respectively). Interpretation & Conclusion: The decreased number of T-regulatory cells and the increased levels of FoxP3 in T-regs from HIV infected patients were associated with advanced stage of AIDS disease.
Subject(s)
Transcription factor FOXP3
Adult
Article
CD4+ T lymphocyte
Cell population
Clinical article
Controlled study
Disease association
Female
Flow cytometry
Fluorescence activated cell sorting
Highly active antiretroviral therapy
Human
Human immunodeficiency virus 1
Human immunodeficiency virus infected patient
Male
Protein expression
Regulatory T lymphocyte
Human immunodeficiency virus 1
Adult
Article
CD4+ T lymphocyte
Cell population
Clinical article
Controlled study
Disease association
Female
Flow cytometry
Fluorescence activated cell sorting
Highly active antiretroviral therapy
Human
Human immunodeficiency virus 1
Human immunodeficiency virus infected patient
Male
Protein expression
Regulatory T lymphocyte
Human immunodeficiency virus 1