Publication:
The burden of norovirus disease in children: a multi-country study in Chile, Brazil, Thailand and the Philippines

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Issued Date

2021

Resource Type

Article

Language

eng

File Type

application/pdf

ISSN

12019712

DOI

10.1016/j.ijid.2021.06.037

Other identifier(s)

2-s2.0-85110538928

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

International Journal of Infectious Diseases. Vol 109, No. (2021), p.77-84

Suggested Citation

Safadi M.A., Riera-Montes M., Bravo L., Tangsathapornpong A., Lagos R., Thisyakorn U., Linhares A.C., Capeding R., Prommalikit O., Verstraeten T., O'Ryan M. The burden of norovirus disease in children: a multi-country study in Chile, Brazil, Thailand and the Philippines. International Journal of Infectious Diseases. Vol 109, No. (2021), p.77-84. doi:10.1016/j.ijid.2021.06.037 Retrieved from: https://hdl.handle.net/20.500.14740/6000

Title

The burden of norovirus disease in children: a multi-country study in Chile, Brazil, Thailand and the Philippines

Author(s)

Safadi M.A.
 Riera-Montes M.
 Bravo L.
 Tangsathapornpong A.
 Lagos R.
 Thisyakorn U.
 Linhares A.C.
 Capeding R.
 Prommalikit O.
 Verstraeten T.
 O'Ryan M.

Abstract

Background: Noroviruses (NoVs) cause acute gastroenteritis (AGE) worldwide, affecting children in particular. We aimed to estimate the burden of disease due to NoV among children aged <6 years in Brazil, Chile, Philippines and Thailand. Methods: This was a prospective, hospital-based, observational study. Children were recruited over one year between 2014 and 2017. Four cohorts were analysed: community-acquired AGE outpatients and inpatients, nosocomial AGE inpatients, and asymptomatic outpatients. We collected demographic and clinical data, and a stool sample that was tested for NoV. Positive samples were tested for Rotavirus (RV) and NoV-genotyped. Disease severity was assessed by the Vesikari and modified Vesikari scores. Prevalence and incidence of NoV-AGE were estimated by cohort and country. Results: 1637 participants yielded valid laboratory results. The proportion of NoV-positive cases was 23.8% (95% CI 20.8-27.2) in the outpatient cohort, 17.9% (15.0-21.3) in the hospital cohort, 21.4% (12.7-33.8) in the nosocomial cohort and 9.6% (6.9-13.2) in the asymptomatic cohort. Genotype GII.4 was predominant (58%). Less than 4% samples had RV coinfection. In general, NoV-positive subjects had more severe presentations than NoV-negative subjects. Conclusions: NoV caused AGE with substantial burden throughout the studied settings, with higher relative frequency in Brazil where RV vaccination coverage is high. © 2021 The Authors

Subject(s)

Acute gastroenteritis
 Article
 Asymptomatic infection
 Brazil
 Child
 Chile
 Clinical feature
 Cohort analysis
 Coinfection
 Community acquired infection
 Disease burden
 Disease severity assessment
 Female
 Global disease burden
 Hospital infection
 Hospital patient
 Human
 Incidence
 Major clinical study
 Male
 Molecular epidemiology
 Nonhuman
 Norovirus
 Norovirus genotype GII.4
 Norovirus infection
 Observational study
 Outpatient
 Philippines
 Prevalence
 Prospective study
 Rotavirus infection
 Thailand
 Calicivirus infection
 Feces
 Genetics
 Genotype
 Infant
 Norovirus
 Virus RNA
 Brazil
 Caliciviridae Infections
 Child
 Chile
 Feces
 Genotype
 Humans
 Infant
 Norovirus
 Philippines
 Prospective Studies
 RNA, Viral
 Thailand

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URI

https://hdl.handle.net/20.500.14740/6000

Collections

Scopus: Year 1983-2021

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