Publication: Combined ECT and neuroleptic therapy in treatment-refractory schizophrenia: Prediction of outcome
3
0
Issued Date
2001
Resource Type
File Type
application/pdf
ISSN
1651781
Other identifier(s)
2-s2.0-0035894087
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Psychiatry Research. Vol 105, (2001), p.107-115
Suggested Citation
Chanpattana W., Somchai Chakrabhand M.L. Combined ECT and neuroleptic therapy in treatment-refractory schizophrenia: Prediction of outcome. Psychiatry Research. Vol 105, (2001), p.107-115. doi:10.1016/S0165-1781(01)00321-3 Retrieved from: https://hdl.handle.net/20.500.14740/6836
Author(s)
Abstract
There have been scanty reports of the clinical features of schizophrenic patients treated with electroconvulsive therapy (ECT). This prospective study examined clinical characteristics and predictive factors associated with therapeutic outcome. Two hundred and ninety-three patients with refractory schizophrenia were treated with a combination of ECT and flupenthixol. Outcome assessments included the Brief Psychiatric Rating Scale (BPRS), the Global Assessment of Functioning (GAF), and the Mini-Mental State Examination (MMSE). One hundred and sixty patients (54.6%) met a response criterion. The responders were younger, had shorter durations of illness and current episode, more admissions, and less family history of schizophrenia. The duration of current episode (t=5.0, P<0.0001), followed by baseline GAF score (t=3.1, P=0.002), duration of illness (t=3.1, P=0.002), baseline MMSE score (t=3.0, P=0.003), duration of the previously failed neuroleptic trials (t=3.0, P=0.003), family history of schizophrenia (t=2.1, P=0.03), and paranoid type (t=2.1, P=0.04), could predict the therapeutic outcome. Treatment resulted in marked improvement in positive symptoms but had a minimal effect or led to a worsening of negative symptoms. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
Subject(s)
Flupentixol
Neuroleptic agent
Adult
Conference paper
Controlled study
Disease course
Disease duration
Electroconvulsive therapy
Family history
Female
Hospital admission
Human
Major clinical study
Male
Mental test
Negative syndrome
Prediction
Priority journal
Rating scale
Schizophrenia
Treatment outcome
Adult
Combined Modality Therapy
Electroconvulsive Therapy
Female
Flupenthixol
Humans
Male
Mental Status Schedule
Prospective Studies
Psychiatric Status Rating Scales
Schizophrenia
Schizophrenic Psychology
Treatment Outcome
Neuroleptic agent
Adult
Conference paper
Controlled study
Disease course
Disease duration
Electroconvulsive therapy
Family history
Female
Hospital admission
Human
Major clinical study
Male
Mental test
Negative syndrome
Prediction
Priority journal
Rating scale
Schizophrenia
Treatment outcome
Adult
Combined Modality Therapy
Electroconvulsive Therapy
Female
Flupenthixol
Humans
Male
Mental Status Schedule
Prospective Studies
Psychiatric Status Rating Scales
Schizophrenia
Schizophrenic Psychology
Treatment Outcome