Publication:
Comparative trial of moisturizer containing licochalcone A vs. hydrocortisone lotion in the treatment of childhood atopic dermatitis: A pilot study

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0

Issued Date

2011

Resource Type

Article

File Type

application/pdf

ISSN

9269959

DOI

10.1111/j.1468-3083.2010.03845.x

Other identifier(s)

2-s2.0-79955928097

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of the European Academy of Dermatology and Venereology. Vol 25, No.6 (2011), p.660-665

Suggested Citation

Udompataikul M., Srisatwaja W. Comparative trial of moisturizer containing licochalcone A vs. hydrocortisone lotion in the treatment of childhood atopic dermatitis: A pilot study. Journal of the European Academy of Dermatology and Venereology. Vol 25, No.6 (2011), p.660-665. doi:10.1111/j.1468-3083.2010.03845.x Retrieved from: https://hdl.handle.net/20.500.14740/7324

Title

Comparative trial of moisturizer containing licochalcone A vs. hydrocortisone lotion in the treatment of childhood atopic dermatitis: A pilot study

Author(s)

Udompataikul M.
 Srisatwaja W.

Abstract

Background Although moisturizer usage has been considered a mainstay of treatment for atopic dermatitis (AD) patients, few clinical studies have been investigated. Recently, moisturizers containing non-steroidal anti-inflammatory agents, such as licochalcone A (LA) and vitamin B12 are of emerging interest. Objective To compare the effectiveness of moisturizer containing LA with hydrocortisone (HC) lotion in treatment of childhood AD. Methods The randomized, controlled, investigator-blinded 6-week study was conducted. Patients were administered with twice-daily application of LA lotion on one side of the body and HC lotion on the opposite side. The clinical outcome was assessed by the scoring of atopic dermatitis (SCORAD) index. The relapse rate was comparatively analysed by survival analysis. Results From 30 patients enrolled, 26 patients completed the protocol. The mean age of the children was 5.8 years. The average baseline SCORAD score is about 28 on both sides. The response rates of both agents were equal to 73.33%. There is no statistical significant group difference in reduction of SCORAD score. Although we observed more rapid resolution of oedema and erythema in areas treated with HC lotion, both agents exhibited no significant difference. The relapse rate of HC group was higher than in LA group; however, there was no significant difference. No side-effect was observed from both agents. Conclusion The effectiveness of LA lotion is equal to that of HC lotion. It was suggested that moisturizer containing LA could be used both for treatment of acute and maintenance phase in mild-to-moderate childhood AD. © 2010 European Academy of Dermatology and Venereology and Venereology.

Subject(s)

Ceramide
 Hydrocortisone
 Lanolin alcohol
 Licochalcone A
 Linoleic acid
 Adolescent
 Article
 Atopic dermatitis
 Child
 Clinical article
 Drug efficacy
 Dry skin
 Edema
 Erythema
 Female
 Human
 Lichenoid eruption
 Lotion
 Male
 Preschool child
 Priority journal
 Pruritus
 Randomized controlled trial
 Recurrence risk
 School child
 Scoring of atopic dermatitis index
 Scoring system
 Skin excoriation
 Statistical significance
 Survival
 Administration, Cutaneous
 Adolescent
 Analysis of Variance
 Anti-Inflammatory Agents
 Chalcones
 Child
 Child, Preschool
 Dermatitis, Atopic
 Emollients
 Female
 Humans
 Hydrocortisone
 Infant
 Kaplan-Meier Estimate
 Male
 Patient Satisfaction
 Pilot Projects
 Recurrence
 Severity of Illness Index
 Single-Blind Method
 Treatment Outcome

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URI

https://hdl.handle.net/20.500.14740/7324

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Scopus: Year 1983-2021

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