Publication:
Anti-HIV-1 reverse transcriptase activities of hexane extracts from some asian medicinal plants

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Issued Date

2011

Resource Type

Article

File Type

application/pdf

ISSN

19960875

Other identifier(s)

2-s2.0-81555216096

Rights Holder(s)

Scopus

Bibliographic Citation

Journal of Medicinal Plant Research. Vol 5, No.19 (2011), p.4899-4906

Suggested Citation

Silprasit K., Seetaha S., Pongsanaraku P., Hannongbua S., Choowongkomon K. Anti-HIV-1 reverse transcriptase activities of hexane extracts from some asian medicinal plants. Journal of Medicinal Plant Research. Vol 5, No.19 (2011), p.4899-4906. Retrieved from: https://hdl.handle.net/20.500.14740/7241

Title

Anti-HIV-1 reverse transcriptase activities of hexane extracts from some asian medicinal plants

Author(s)

Silprasit K.
 Seetaha S.
 Pongsanaraku P.
 Hannongbua S.
 Choowongkomon K.

Abstract

Numerous herbal remedies against viral infections, including HIV-1, have been used as a part of Asian traditional medicine. However, the viral protein targets for inhibition by these medications are less well identified. HIV-1 reverse transcriptase is one of the targets, since high-efficiency inhibitors such as nonnucleoside HIV-1 reverse transcriptase inhibitor have been successfully used. In this work, hexane extracts of Asian medicinal plants were screened against HIV-1 reverse transcriptase. The results showed that the crude extracts from plants Cinnamomum loureiroi (stem bark), Quercus infectoria (fruit), Plumbago indica L. (root), Artocarpus heterophyllus Lam. (seed), Ocimum sanctum L. (leaves), Allium sativum L. (bulb) and Acorus calamus L. (rhizomes) showed strong HIV-1 reverse transcriptase inhibitory effects. The efficiency of anti-HIV-1RT activity was reported as 50% inhibitory concentrations (IC 50). This showed that the hexane crude extracts from A. calamus L. and A. heterophyllus Lam. contained potent activity against HIV-1 RT, with IC 50 of 32.96 ± 3.17 and 34.69 ± 2.41 μg/ml, respectively. © 2011 Academic Journals.

Subject(s)

Acorus calamus extract
 Artocarpus heterophyllus extract
 Cinnamomum loureiroi extract
 Garlic extract
 Ocimum tenuiflorum extract
 Plant extract
 Plumbago indica extract
 Quercus infectoria extract
 RNA directed DNA polymerase
 RNA directed DNA polymerase inhibitor
 Unclassified drug
 Article
 Artocarpus heterophyllus
 Asian
 Bark
 Cinnamomum loureiroi
 Controlled study
 Drug effect
 Drug efficacy
 Drug mechanism
 Drug potency
 Enzyme assay
 Enzyme inhibition
 Fluorescence analysis
 Fruit
 Hydrophobicity
 IC 50
 Medicinal plant
 Nonhuman
 Ocimum tenuiflorum
 Plant bulb
 Plant leaf
 Plant root
 Plant seed
 Plant stem
 Plumbago indica
 Quercus infectoria
 Rhizome
 Acorus calamus
 Allium sativum
 Artocarpus heterophyllus
 Cinnamomum
 Human immunodeficiency virus 1
 Ocimum tenuiflorum
 Plumbago indica
 Quercus infectoria

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URI

https://hdl.handle.net/20.500.14740/7241

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Scopus: Year 1983-2021

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