Publication:
Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients

0
0

Issued Date

2019

Resource Type

Article

File Type

application/pdf

ISSN

1354523X

DOI

10.1111/odi.13151

Other identifier(s)

2-s2.0-85070114086

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Oral Diseases. Vol 25, No.7 (2019), p.1798-1808

Suggested Citation

Tarapan S., Matangkasombut O., Trachootham D., Sattabanasuk V., Talungchit S., Paemuang W., Phonyiam T., Chokchaitam O., Mungkung O.-O., Lam-Ubol A. Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients. Oral Diseases. Vol 25, No.7 (2019), p.1798-1808. doi:10.1111/odi.13151 Retrieved from: https://hdl.handle.net/20.500.14740/5131

Title

Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients

Author(s)

Tarapan S.
 Matangkasombut O.
 Trachootham D.
 Sattabanasuk V.
 Talungchit S.
 Paemuang W.
 Phonyiam T.
 Chokchaitam O.
 Mungkung O.-O.
 Lam-Ubol A.

Abstract

Objectives: To evaluate (a) oral colonization of Candida species, especially for non-albicans Candida species (NACS), in xerostomic postradiotherapy head and neck cancer patients and (b) risk factors affecting their colonization. Materials and methods: Subjective and objective dry mouth scores, stimulated salivary flow rates, pH and buffering capacity were measured in 72 xerostomic postradiotherapy head and neck cancer patients. Candida counts and species identification were performed using oral rinse samples cultured in Candida Chromagar, followed by polymerase chain reaction and API 20C AUX system. Results: Candida colonization was observed in 87.5% of subjects, with 80.6% and 48.6% of study population colonized by C. albicans and NACS, respectively. NACS was associated with high objective dry mouth scores, denture use, and females (p =.006,.009, and.036, respectively). In addition, Candida glabrata was detected more in females (p =.018) and denture wearers (p =.026), while Candida tropicalis was associated with high objective dry mouth scores (p =.022) and females (p =.027). Quantity of Candida colonization correlated positively with objective dry mouth scores (r = 0.599, p <.001) and negatively with salivary flow rates (r = −0.258, p =.041) and pH (r = −0.290, p =.022). Conclusion: NACS colonization was common in xerostomic head and neck cancer patients. Increased signs of dry mouth, female and dental prostheses may promote NACS colonization. © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved

Subject(s)

Adult
 Aged
 Article
 Cancer radiotherapy
 Candida
 Candida albicans
 Candida glabrata
 Candida tropicalis
 Clinical trial
 Female
 Fungal colonization
 Head and neck cancer
 Human
 Major clinical study
 Male
 Mouth
 Nonhuman
 PH
 Polymerase chain reaction
 Priority journal
 Risk factor
 Salivation
 Scoring system
 Xerostomia
 Bacterial count
 Candida
 Drug effect
 Growth, development and aging
 Head and neck tumor
 Metabolism
 Microbiology
 Middle aged
 Mouth
 Radiation response
 Saliva
 Salivary gland
 Secretion rate
 Thrush
 Xerostomia
 Adult
 Aged
 Candida
 Candida albicans
 Candidiasis, Oral
 Colony Count, Microbial
 Female
 Head and Neck Neoplasms
 Humans
 Middle Aged
 Mouth
 Saliva
 Salivary Glands
 Secretory Rate
 Xerostomia

View online Resources

Research Projects

Organizational Units

Journal Issue

URI

https://hdl.handle.net/20.500.14740/5131

Collections

Scopus: Year 1983-2021

Endorsement

Review

Supplemented By

Referenced By