Publication:
Estrogen reduces BDNF level, but maintains dopaminergic cell density in the striatum of MPTP mouse model

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Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

207454

DOI

10.3109/00207451003721892

Other identifier(s)

2-s2.0-77954206062

Rights Holder(s)

Scopus

Bibliographic Citation

International Journal of Neuroscience. Vol 120, No.7 (2010), p.489-495

Suggested Citation

Tripanichkul W., Gerdprasert O., Jaroensuppaperch E.-O. Estrogen reduces BDNF level, but maintains dopaminergic cell density in the striatum of MPTP mouse model. International Journal of Neuroscience. Vol 120, No.7 (2010), p.489-495. doi:10.3109/00207451003721892 Retrieved from: https://hdl.handle.net/20.500.14740/7587

Title

Estrogen reduces BDNF level, but maintains dopaminergic cell density in the striatum of MPTP mouse model

Author(s)

Tripanichkul W.
 Gerdprasert O.
 Jaroensuppaperch E.-O.

Abstract

Degeneration of dopaminergic (DA) axons in the striatum triggers upregulation of striatal trophic activity and striatal DA neuronal number in animal models of Parkinson's disease (PD). The present study investigated the effects of 17β-estradiol (E2) on brain-derived neurotrophic factor (BDNF) expression and the density of DA neurons in the striatum of 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP) mouse model in correlation with nigrostriatal DA innervation. Adult male C57Bl/6 mice were treated with E2 or vehicle for 11 days. Following 5 days of E2 or vehicle pretreatment, animals were injected with MPTP on day 6. On day 11, all mice were sacrificed, and the striatum were collected and processed for tyrosine hydroxylase (TH) and BDNF immunohistochemistry. Striatal TH-immunoreactive (IR) neurons were counted. Extent of DA innervation and BDNF expression in the striatum were assessed by measuring optical density of TH and BDNF immunoreactivity, respectively. Pretreatment with E2 partially prevented DA denervation and decreased striatal BDNF upregulation triggered by MPTP, but maintained the density of striatal TH-IR neurons to that observed in MPTP group. These findings suggest that estrogen protection of nigrostriatal DA axons against MPTP as well as preservation of the striatal TH-IR cell density in MPTP/E2 mice may be not mediated by BDNF. Copyright © 2010 Informa Healthcare USA, Inc.

Subject(s)

1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine
 Brain derived neurotrophic factor
 Estradiol
 Tyrosine 3 monooxygenase
 Animal experiment
 Animal model
 Article
 C57BL 6 mouse
 Cell density
 Controlled study
 Corpus striatum
 Dopaminergic nerve cell
 Drug effect
 Female
 Immunohistochemistry
 Immunoreactivity
 Innervation
 Male
 Mouse
 Nerve fiber
 Nonhuman
 Optical density
 Preservation
 Protein expression
 Upregulation
 Animals
 Axons
 Brain-Derived Neurotrophic Factor
 Corpus Striatum
 Disease Models, Animal
 Disease Progression
 Dopamine
 Down-Regulation
 Estrogens
 Male
 Mice
 Mice, Inbred C57BL
 Neuroprotective Agents
 Parkinsonian Disorders
 Substantia Nigra
 Wallerian Degeneration

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URI

https://hdl.handle.net/20.500.14740/7587

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Scopus: Year 1983-2021

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