Publication:
Stem cell based therapy in the inner ear: Appropriate donor cell types and routes for transplantation

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Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

13894501

DOI

10.2174/138945010791320836

Other identifier(s)

2-s2.0-77954717756

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Current Drug Targets. Vol 11, No.7 (2010), p.888-897

Suggested Citation

Jongkamonwiwat N., Zine A., Rivolta M.N. Stem cell based therapy in the inner ear: Appropriate donor cell types and routes for transplantation. Current Drug Targets. Vol 11, No.7 (2010), p.888-897. doi:10.2174/138945010791320836 Retrieved from: https://hdl.handle.net/20.500.14740/7561

Title

Stem cell based therapy in the inner ear: Appropriate donor cell types and routes for transplantation

Author(s)

Jongkamonwiwat N.
 Zine A.
 Rivolta M.N.

Abstract

Losing one of our main sensory systems such as hearing can have devastating consequences in the way we interact with the world. The main problem lies in the fact that the critical sensory cells, the auditory neurons and hair cells located in the cochlea are only generated during development and, when damaged, cannot be replaced. The options currently available to treat this condition are very limited, and are mostly represented by prosthetic devices such as hearing aids and cochlear implants. There is a clear need for a therapeutic breakthrough that will help the millions of people affected, and the advances in stem cell technologies are offering a glimmer of hope for this affliction. Although still at a very early stage, a growing bulk of literature is being produced attempting to pave the path for a stem cell-based therapy for deafness. From the many variables to bear in mind when developing this approach, two appear to be of paramount importance. First, different cell types are potentially to be used, all of them having advantages and disadvantages. Second, in order to target such a small and secluded organ as the cochlea, difficult surgical techniques are to be used, some of which still need to be developed. The present article will aim to present the most recent advances of the field, focussing on these two critical issues. © 2010 Bentham Science Publishers Ltd.

Subject(s)

Ciliary neurotrophic factor
 Doxycycline
 Neurogenin 1
 Neurotrophic factor
 Article
 Cell type
 Cochlea duct
 Cochlea prosthesis
 Cochlear nerve
 Cochlear nucleus
 Corti organ
 Ear protection
 Embryonic stem cell
 Hearing impairment
 Human
 Inner ear
 Mesenchymal stem cell
 Mesenchymal stem cell transplantation
 Neural stem cell
 Nonhuman
 Pluripotent stem cell
 Protein expression
 Spiral ganglion
 Stem cell transplantation
 Surgical technique
 Animals
 Cochlea
 Cochlear Implantation
 Deafness
 Hair Cells, Auditory
 Humans
 Models, Anatomic
 Nerve Growth Factors
 Regeneration
 Sensory Receptor Cells
 Stem Cell Transplantation
 Stem Cells

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URI

https://hdl.handle.net/20.500.14740/7561

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Scopus: Year 1983-2021

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