Publication:
Non-Hodgkin lymphoma in South East Asia: An analysis of the histopathology, clinical features, and survival from Thailand

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Issued Date

2018

Resource Type

Article

File Type

application/pdf

ISSN

2780232

DOI

10.1002/hon.2392

Other identifier(s)

2-s2.0-85017382024

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Hematological Oncology. Vol 36, No.1 (2018), p.28-36

Suggested Citation

Intragumtornchai T., Bunworasate U., Wudhikarn K., Lekhakula A., Julamanee J., Chansung K., Sirijerachai C., Norasetthada L., Nawarawong W., Khuhapinant A., Siritanaratanakul N., Numbenjapon T., Prayongratana K., Chuncharunee S., Niparuck P., Suwanban T., Kanitsap N., Wongkhantee S., Pornvipavee R., Wong P., Makruasi N., Wannakrairot P., Assanasen T., Sukpanichnant S., Boonsakan P., Kanoksil W., Ya-In C., Kayasut K., Mitranun W., Warnnissorn N. Non-Hodgkin lymphoma in South East Asia: An analysis of the histopathology, clinical features, and survival from Thailand. Hematological Oncology. Vol 36, No.1 (2018), p.28-36. doi:10.1002/hon.2392 Retrieved from: https://hdl.handle.net/20.500.14740/3718

Title

Non-Hodgkin lymphoma in South East Asia: An analysis of the histopathology, clinical features, and survival from Thailand

Author(s)

Intragumtornchai T.
 Bunworasate U.
 Wudhikarn K.
 Lekhakula A.
 Julamanee J.
 Chansung K.
 Sirijerachai C.
 Norasetthada L.
 Nawarawong W.
 Khuhapinant A.
 Siritanaratanakul N.
 Numbenjapon T.
 Prayongratana K.
 Chuncharunee S.
 Niparuck P.
 Suwanban T.
 Kanitsap N.
 Wongkhantee S.
 Pornvipavee R.
 Wong P.
 Makruasi N.
 Wannakrairot P.
 Assanasen T.
 Sukpanichnant S.
 Boonsakan P.
 Kanoksil W.
 Ya-In C.
 Kayasut K.
 Mitranun W.
 Warnnissorn N.

Abstract

Systemic reports on the descriptive epidemiology of non-Hodgkin lymphoma (NHL) from Southeast Asia are scarce. A nationwide multi-institutional registry was conducted to compare the histopathology, clinical features, and survival of Thai adult patients with NHL using large registries, especially those from Far East Asia (FEA). Using a web-based registry system, 13 major medical centers from the 4 geographic regions of Thailand prospectively collected, from 2007 to 2014, the diagnostic pathology, according to the World Health Organization classification, 2008, clinical features and survival of 4056 patients who were newly diagnosed with NHL. The median age of the patients was 56 years (range, 16-99 years). The male-to-female ratio was 1.3:1. From the total of 4056 patients, T/NK-cell lymphoma (TNKCL) accounted for 12.6% of cases, and 5.1% had human immunodeficiency virus–associated lymphoma. The four leading histological subtypes were diffuse large B-cell lymphoma, not otherwise specified (58.1%); follicular lymphoma (5.6%); extranodal mucosa-associated lymphoid tissue lymphoma (5.2%); and peripheral T-cell lymphoma, not otherwise specified (4.0%). With a median follow-up duration of 46.1 months, the median overall survival of B-cell NHL was significantly longer than that of patients with TNKCL (76.5 vs 28.8 months, P =.0001). Compared to FEA, the Thai registry had an approximately one-half lower relative frequency of TNKCL; the prevalence of extranodal mucosa-associated lymphoid tissue lymphoma was much lower than in Korea, and the frequency of extranodal TNKCL, nasal type, was strikingly low compared to China. It is concluded that while the median age of Thai patients with NHL was approximately a decade younger than for Caucasians, the long-term survival rates for most histological subtypes were comparable. While the histological distribution generally complied with the characteristic Asian features, some differences from FEA were observed. Copyright © 2017 John Wiley & Sons, Ltd.

Subject(s)

Anaplastic lymphoma kinase
 Cyclophosphamide
 Doxorubicin
 Prednisolone
 Rituximab
 Vincristine
 Adult
 Aged
 Anaplastic large cell lymphoma
 Article
 B cell lymphoma
 Cancer chemotherapy
 Cancer survival
 China
 Clinical feature
 Cohort analysis
 Comparative study
 Diffuse large B cell lymphoma
 Female
 Follicular lymphoma
 Follow up
 Histology
 Histopathology
 Human
 Human immunodeficiency virus infection
 Human tissue
 Korea
 Long term survival
 Lymphoblastoma
 Major clinical study
 Male
 Marginal zone lymphoma
 Middle aged
 NK T cell lymphoma
 Nonhodgkin lymphoma
 Overall survival
 Peripheral T cell lymphoma
 Prevalence
 Priority journal
 Subcutaneous t cell lymphoma
 Thailand
 Adolescent
 Mortality
 Nonhodgkin lymphoma
 Pathophysiology
 Southeast Asia
 Survival analysis
 Thailand
 Very elderly
 Young adult
 Adolescent
 Adult
 Aged
 Aged, 80 and over
 Asia, Southeastern
 Female
 Humans
 Lymphoma, Non-Hodgkin
 Male
 Middle Aged
 Survival Analysis
 Thailand
 Young Adult

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https://hdl.handle.net/20.500.14740/3718

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Scopus: Year 1983-2021

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