Publication:
Physicochemical properties and anti-Propionibacterium acnes activity of film-forming solutions containing alpha-mangostin-rich extract

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Issued Date

2014

Resource Type

Article

File Type

application/pdf

ISSN

15309932

DOI

10.1208/s12249-013-0057-8

Other identifier(s)

2-s2.0-84898052782

Rights Holder(s)

Scopus

Bibliographic Citation

AAPS PharmSciTech. Vol 15, No.2 (2014), p.306-316

Suggested Citation

Asasutjarit R., Larpmahawong P., Fuongfuchat A., Sareedenchai V., Veeranondha S. Physicochemical properties and anti-Propionibacterium acnes activity of film-forming solutions containing alpha-mangostin-rich extract. AAPS PharmSciTech. Vol 15, No.2 (2014), p.306-316. doi:10.1208/s12249-013-0057-8 Retrieved from: https://hdl.handle.net/20.500.14740/6370

Title

Physicochemical properties and anti-Propionibacterium acnes activity of film-forming solutions containing alpha-mangostin-rich extract

Author(s)

Asasutjarit R.
 Larpmahawong P.
 Fuongfuchat A.
 Sareedenchai V.
 Veeranondha S.

Abstract

The objective of this study was to study the effect of formulation compositions on physicochemical properties and anti-Propionibacterium acnes activity of film-forming solutions containing alpha-mangostin-rich extract (AM). Film-forming solution bases and film-forming solutions containing AM were prepared by using Eudragit RL PO or Klucel LF or combinations of them as film-forming polymers. Rheological properties, pH values of the solutions, and mechanical properties of the dry films were investigated. An optimized formulation was selected and evaluated for the film surface, in vitro AM release, an anti-P. acnes activity, and potential for being a skin irritant. It was found that mechanical properties of the dry films were affected by total polymer contents, ratios of Klucel LF/Eudragit RL PO, AM, and contents of triethyl citrate. The film-forming solutions containing AM had pH values around 7.0. Their flow curves exhibited Newtonian flow behaviors. The optimized formulation provided films possessing smooth and nonporous surfaces. These films showed greater anti-P. acnes activity than their base films without toxicity to skin fibroblasts. Furthermore, AM released from the film matrix obeyed Higuchi's equation. In conclusion, the film-forming solutions containing AM had potential for treatment of acne vulgaris caused by P. acnes. However, further in vivo study is necessary to determine their efficacy and safety for using in patients suffering from acne vulgaris. © 2013 American Association of Pharmaceutical Scientists.

Subject(s)

Alpha mangostin rich extract
 Anti acne agent
 Antiinfective agent
 Citric acid triethyl ester
 Dichloromethane
 Eudragit
 Hydroxypropylcellulose
 Irritant agent
 Plasticizer
 Polymer
 Unclassified drug
 Antiinfective agent
 Mangostin
 Plant extract
 Solution and solubility
 Xanthone derivative
 Acne vulgaris
 Antibacterial activity
 Article
 Bacterial growth
 Cell membrane
 Column chromatography
 Dialysis membrane
 Disk diffusion
 Drug formulation
 Drug release
 Elasticity
 Film forming solution
 Flow kinetics
 Hardness
 High performance liquid chromatography
 Higuchi equation
 Human
 Human cell
 Hydrogen bond
 Hydrophobicity
 Infrared spectroscopy
 Mathematical model
 Minimum inhibitory concentration
 MTT assay
 Newtonian flow
 PH
 Physical chemistry
 Phytochemistry
 Priority journal
 Propionibacterium acnes
 Scanning electron microscopy
 Shear stress
 Skin fibroblast
 Skin irritation
 Surface property
 Tensile strength
 Thin layer chromatography
 Viscosity
 Chemistry
 Drug effects
 Garcinia mangostana
 Microbial sensitivity test
 Propionibacterium acnes
 Solution and solubility
 Anti-Bacterial Agents
 Chromatography, Thin Layer
 Garcinia mangostana
 Microbial Sensitivity Tests
 Plant Extracts
 Propionibacterium acnes
 Solutions
 Spectroscopy, Fourier Transform Infrared
 Xanthones

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URI

https://hdl.handle.net/20.500.14740/6370

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Scopus: Year 1983-2021

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