Publication:
Binding antibody to neutralizing epitope gp41 in HIV-1 subtype CRF 01_AE infection related to stage of disease

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Issued Date

2005

Resource Type

Article

File Type

application/pdf

ISSN

1251562

Other identifier(s)

2-s2.0-17744370178

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Southeast Asian Journal of Tropical Medicine and Public Health. Vol 36, No.1 (2005), p.221-227

Suggested Citation

Srisurapanon S., Louisirirotchanakul S., Sumransurp K., Ratanasrithong M., Chuenchitra T., Jintakatkorn S., Wasi C. Binding antibody to neutralizing epitope gp41 in HIV-1 subtype CRF 01_AE infection related to stage of disease. Southeast Asian Journal of Tropical Medicine and Public Health. Vol 36, No.1 (2005), p.221-227. Retrieved from: https://hdl.handle.net/20.500.14740/6319

Title

Binding antibody to neutralizing epitope gp41 in HIV-1 subtype CRF 01_AE infection related to stage of disease

Author(s)

Srisurapanon S.
 Louisirirotchanakul S.
 Sumransurp K.
 Ratanasrithong M.
 Chuenchitra T.
 Jintakatkorn S.
 Wasi C.

Abstract

The responsiveness of gp41 antibody against epitope ELDKWA in HIV-1 infected subjects is of importance in neutralizing viral infectivity and for being related to disease progression. In this study, antibody titers to this neutralizing epitope from HIV-1 infected subjects at asymptomatic and AIDS stages in Thailand were investigated by peptide ELISA. The results showed that the frequency of antibody production against this neutralizing epitope was low (15-35%). Moreover, antibody titers to this epitope in sera from AIDS patients were significantly lower than those in sera from asymptomatic subjects which were collected in the same year (p=0.001). Comparison between the past (1992-1994) and present (2002) sera from asymptomatic infected individuals revealed that the earlier panel contained lower antibody titers than the later panel did (p=0.05). In addition, random sera for HIV-1 infected subjects who were infected by diverse genetic subtypes, (A through G) including CRF 01_AE, had low titers of antibody to this region as well. It is assumed that antibody production to this epitope is low and related to the stage of HIV-1 infection.

Subject(s)

Epitope
 Glutamylleucylaspartyllysyltryptophylalanine
 Glycoprotein gp 41 antibody
 Neutralizing antibody
 Protein antibody
 Unclassified drug
 Amino acid sequence
 Antibody production
 Antibody titer
 Antigen binding
 Article
 Blood analysis
 Blood sampling
 Controlled study
 Disease association
 Disease classification
 Disease course
 Disease severity
 Enzyme linked immunosorbent assay
 Frequency analysis
 Genetic variability
 Human
 Human immunodeficiency virus 1
 Human immunodeficiency virus infection
 Major clinical study
 Peptide analysis
 Randomization
 Statistical significance
 Symptomatology
 Thailand
 Viral genetics
 Virus infectivity
 Virus typing

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URI

https://hdl.handle.net/20.500.14740/6319

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Scopus: Year 1983-2021

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