Publication: C-reactive protein, interleukin-6, and tumor necrosis factor-α levels in overweight and healthy adults
0
0
Issued Date
2006
Resource Type
File Type
application/pdf
ISSN
1251562
Other identifier(s)
2-s2.0-33746103637
Rights Holder(s)
Scopus
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol 37, No.2 (2006), p.374-381
Suggested Citation
Chaikate S., Harnroongroj T., Chantaranipapong Y., Puduang S., Mahaisiriyodom A., Viroonudomphol D., Singhasivanon P., Schelp F.P., Tornee S., Tribunyatkul S., Changbumrung S. C-reactive protein, interleukin-6, and tumor necrosis factor-α levels in overweight and healthy adults. Southeast Asian Journal of Tropical Medicine and Public Health. Vol 37, No.2 (2006), p.374-381. Retrieved from: https://hdl.handle.net/20.500.14740/6005
Abstract
This study aimed to 1) compare levels of high sensitivity c-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) between overweight Thais and apparently healthy controls, and 2) investigate the association between serum hs-CRP, IL-6, and TNF-α levels and other biochemical parameters. A total of 180 health-conscious adults aged 25-60 years, who resided in Bangkok, participated in this study. No significant difference was found in age and sex between the overweight subjects and controls. Serum levels of hs-CRP, IL-6, TNF-α, glucose, lipid profile, body mass index (BMI), waist circumference (WC), hip circumference (HC) and waist hip ratio (WHR) were determined in these volunteers. The mean levels of white blood cells (WBC), uric acid, total cholesterol (TC), triglyceride (TG), and hs-CRP were significantly higher in the overweight subjects than those in the controls, whereas high density lipoprotein-cholesterol (HDL-C) values were significantly higher in the controls than the overweight subjects (p<0.05). Hs-CRP levels were significantly positively correlated with levels of TG, BMI, WC, HC and WHR. HDL-C levels were significantly negative correlated with hs-CRP levels. In conclusion, the prevalence of elevated serum hs-CRP levels was higher in overweight subjects than controls. However, more data in larger and other population groups are needed to confirm this study.