Publication:
Dengue associated haemophagocytic lymphohystiocytosis: An often-missed complication of a common infection

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Issued Date

2020

Resource Type

Article

File Type

application/pdf

ISSN

3005283

Other identifier(s)

2-s2.0-85090571298

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Medical Journal of Malaysia. Vol 75, No.5 (2020), p.588-590

Suggested Citation

Takkinsatian P., Sowithayasakul P., Prommalikit O. Dengue associated haemophagocytic lymphohystiocytosis: An often-missed complication of a common infection. Medical Journal of Malaysia. Vol 75, No.5 (2020), p.588-590. Retrieved from: https://hdl.handle.net/20.500.14740/4410

Title

Dengue associated haemophagocytic lymphohystiocytosis: An often-missed complication of a common infection

Author(s)

Takkinsatian P.
 Sowithayasakul P.
 Prommalikit O.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a severe and life-threatening condition causing multisystem involvement such as cytopenia, hepatosplenomegaly, and death. Dengue infection is one of the leading causes of HLH. We reviewed three cases of children at HRH Princess Maha Chakri Sirindhorn Medical Center, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand, with dengue fever who subsequently developed HLH, based on the HLH-2004 diagnostic criteria. Following treatment with dexamethasone and intravenous immunoglobulin, there was a dramatic response including defervescence and improvement of cytopenia, hyperfibrinogenemia, and hyperferritinemia. Key features for diagnosis of dengue fever complicated by HLH include a history of prolonged fever exceeding seven days, splenomegaly, and worsening cytopenia. Early recognition and treatment are crucial for a successful outcome. © 2020, Malaysian Medical Association. All rights reserved.

Subject(s)

Antinuclear antibody
 Cefotaxime
 Dexamethasone
 Immunoglobulin
 Nonstructural protein 1
 Triacylglycerol
 Adolescent
 Anemia
 Article
 Blood cell count
 Bone marrow biopsy
 Case report
 Child
 Clinical article
 Cytomegalovirus
 Cytopenia
 Dengue
 Deterioration
 Erythrophagocytosis
 Female
 Ferritin blood level
 Fever
 Fibrinogen blood level
 Headache
 Hemophagocytic syndrome
 Hepatomegaly
 Hepatosplenomegaly
 Human
 Hyperferritinemia
 Hypertransaminasemia
 Hypofibrinogenemia
 Leukopenia
 Male
 Myalgia
 Pancytopenia
 Pleura effusion
 Polymerase chain reaction
 Preschool child
 Splenomegaly
 Thrombocytopenia
 Verner Morrison syndrome
 Vomiting

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URI

https://hdl.handle.net/20.500.14740/4410

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Scopus: Year 1983-2021

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